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Rabbit Anti-Bone Sialoprotein Polyclonal Antibody#abs137215

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Description

Catalog-specification	Delivery time	USD price
abs137215-100ug	1-2 Weeks	301.0
abs137215-50ug	1-2 Weeks	201.0

Overview
catalog	abs137215
Other names	Sial_Human, also known as BNSP or Bone Sialoprotein 2, is a cell-binding sialoprotein that plays an important role in bone development and regeneration. It is also referred to as Bone Sialoprotein II or BSP II. This integrin-binding sialoprotein, encoded by IBSP gene, possesses unique properties that contribute to cell adhesion and signaling in the extracellular matrix. BNSP, as an integrin-binding protein, interacts with specific integrin receptors on cell surfaces, facilitating cell adhesion to the surrounding matrix. This interaction is crucial for various cellular processes, including cell migration, proliferation, and differentiation. Notably, BNSP is predominantly expressed in mineralized tissues such as bone and teeth, where it promotes the mineralization process. It acts as a nucleator for hydroxyapatite deposition, a major component of bone, and regulates the crystal growth during bone formation. Additionally, BNSP has been implicated in the recruitment and differentiation of osteoblasts, which are responsible for bone formation. Furthermore, BNSP is involved in the modulation of cell signaling pathways. It has been shown to enhance the activation of various signaling molecules, such as focal adhesion kinase (FAK) and extracellular signal-regulated kinases (ERKs), leading to downstream effects on cell behavior and gene expression. The diverse functions of BNSP highlight its importance in bone physiology and pathology. It has been implicated in various skeletal disorders, including osteoporosis and osteoarthritis, suggesting its therapeutic potential as a target for treatment or prevention strategies. In conclusion, Bone Sialoprotein 2, also known as Sial_Human, BSP, or IBSP, is an integrin-binding sialoprotein that plays a crucial role in bone biology. Its involvement in cell adhesion, mineralization, and signaling pathways underscores its significance in bone development and regeneration. Further research on BNSP may provide valuable insights into skeletal disorders and novel therapeutic approaches.
Source	Rabbit
Specificity	The detection of endogenous levels of total Bone Sialoprotein can be achieved using the Bone Sialoprotein Antibody. This antibody specifically recognizes and binds to Bone Sialoprotein, allowing for accurate measurement of its presence. By detecting the endogenous levels of total Bone Sialoprotein, researchers can gain valuable insights into its role and function in various biological processes.
Species Reactivity	Human;Mouse;Rat
Antigen	Bone Sialoprotein
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A proprietary peptide created from human Bone Sialoprotein demonstrates significant similarity to the original content, with a rearrangement of the information to produce an alternative linguistic expression.
MW	35 kDa.
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed in purifying the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of 12 months. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this may affect its integrity and efficacy over time.
Storage buffer	This product contains rabbit IgG in a phosphate buffered saline solution with a pH of 7.4, along with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20 °C and is stable for 12 months from the date of receipt. To ensure maximum quality and efficacy, please handle and store this product as directed. Thank you for choosing our product, and please do not hesitate to contact us with any questions or concerns.
Target
Background	Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
Posttranslational modification	N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains.O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc.Sulfated on either Tyr-313 or Tyr-314.
Celluar localization	Extracellular region or secreted;
UniPort	P21815