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Rabbit Anti-ELAVL1 Polyclonal Antibody#abs136016

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Description

Catalog-specification	Delivery time	USD price
abs136016-100ug	1-2 Weeks	301.0
abs136016-50ug	1-2 Weeks	201.0

Overview
catalog	abs136016
Description	The RNA-binding protein encoded by this gene belongs to the ELAVL family, characterized by several RNA recognition motifs that selectively bind to AU-rich elements (AREs) in the 3' untranslated regions (UTRs) of mRNAs. AREs aid in the degradation of mRNAs, controlling gene expression, and are stabilized by the ELAVL family by binding to them. This gene is associated with various biological processes and has been linked to diseases such as cancer, as it is highly expressed in many cancers. This indicates its probable use in cancer diagnosis, prognosis, and therapy. [RefSeq, Sep 2012].
Other names	ELAV like 1 (also known as embryonic lethal abnormal vision Drosophila like 1) is a protein in humans that is similar to the ELAV (embryonic lethal, abnormal vision, Drosophila) protein found in fruit flies. It is also called Hu antigen R or HuR. ELAV like 1 is an RNA binding protein that plays a role in various cellular processes. It is involved in the regulation of gene expression and has been implicated in the development and function of the nervous system. ELAV like 1 is also known as Hua or MelG.
Source	Rabbit
Specificity	Total ELAVL1 levels can be detected by using ELAVL1 Antibody, which specifically recognizes endogenous levels of the protein. Essentially, this means that this antibody can be used to identify the presence of ELAVL1 in a sample, and is an excellent tool for researchers looking to study this protein. It is important to note that this antibody will only detect total levels of ELAVL1, and will not distinguish between the various isoforms of the protein. However, for many research applications, this level of specificity is sufficient. Ultimately, the ELAVL1 Antibody is a valuable resource for researchers looking to understand the role that ELAVL1 plays in cellular processes and disease.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Rabbit;Pig;Dog;Sheep;Bovine;Horse
Antigen	ELAVL1
Application	The recommended dilution range for WB is between 1:500 and 1:2000, for IHC it is between 1:50 and 1:200, and for IF/ICC it falls between 1:100 and 1:500. Meanwhile, for ELISA (peptide) testing, the dilution range typically lies between 1:20,000 and 1:40,000. It is important to follow these guidelines for accurate and reliable results in your experiments.
Immunogen	A synthesized peptide derived from human ELAVL1.
MW	36kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).
Tissue specificity	Ubiquitous. Detected in brain, liver, thymus and muscle.
Posttranslational modification	Phosphorylated by MAPKAPK2 (PubMed:14517288). Phosphorylated by PRKCD (PubMed:18285462).Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
Celluar localization	Cytosol;Nucleus;
UniPort	Q15717