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Rabbit Anti-P2RY13 Polyclonal Antibody#abs135441

Please note that the price mentioned above is only for your reference. If you require detailed pricing information, please do not hesitate to contact our seller, Vecent. Western blot analysis of extracts from HeLa cells, COLO cells, HT-29 cells, HepG2 cells and HUVEC cells, using P2RY13...

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Description

Catalog-specification	Delivery time	USD price
abs135441-100ug	1-2 Weeks	301.0
abs135441-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. If you require detailed pricing information, please do not hesitate to contact our seller, Vecent.

Overview
catalog	abs135441
Other names	Here are some possible variations: - The gene P2RY13 encodes a purinergic receptor known as P2Y13, which belongs to the family of G protein-coupled receptors (GPCRs). P2Y13 is also referred to as GPR86 or GPR94, and is associated with various physiological functions such as regulation of insulin secretion, adipocyte differentiation, and platelet aggregation. The protein has 317 amino acids and is highly conserved among vertebrates, with a sequence identity of over 90% between human and mouse orthologues. SP174 is a synthetic agonist of P2Y13, which has been used to explore the pharmacology and signal transduction of this receptor. - FKSG77 is a potential alias or mutation of P2RY13, a gene that encodes a G protein-coupled receptor known as P2Y13. P2Y13 is one of the several purinergic receptors that respond to extracellular ATP or ADP, and activate signaling pathways through the activation of Gi/o proteins. P2Y13 is expressed in various tissues including brain, pancreas, and adipose tissue, and has been implicated in glucose homeostasis, insulin secretion, and lipolysis. GPCR1, GPR86, and GPR94 are all synonyms of P2Y13, depending on the source of the data or the context of the research. - The human gene P2RY13 codes for a transmembrane protein that belongs to the P2Y subfamily of purinergic receptors. This protein is designated as P2Y13 or G protein-coupled receptor 86/94, depending on the nomenclature system used. P2Y13 is activated by ATP and ADP, and signals through the inhibition of adenylate cyclase and the activation of inward rectifying potassium channels. P2Y13 has been reported to have a role in glucose-induced insulin secretion in pancreatic beta cells, and to modulate adipogenesis in white adipose tissue. HGNC:13661 refers to the official symbol for the P2RY13 gene, as designated by the HUGO Gene Nomenclature Committee.
Source	Rabbit
Specificity	The total P2RY13 levels can be effectively detected by using the P2RY13 antibody, which specifically recognizes endogenous P2RY13. By rearranging the provided information, a similar content can be generated as follows: The detection of total P2RY13 can be achieved using the P2RY13 antibody, which has a high affinity for endogenous P2RY13.
Species Reactivity	Human;Rat
Antigen	P2RY13
Application	WB 1:500~1:1000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	38 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification. The process resulted in a highly purified antiserum that is closely related to the original sample.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a maximum period of one year. The substance should not be subjected to repeated cycles of freezing and thawing as it may affect its stability and efficiency. It is essential to take precautions to ensure that the product's integrity is preserved during storage.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20°C in a solution of phosphate buffered saline (pH 7.4), containing NaCl at a concentration of 150mM, sodium azide at a concentration of 0.02%, and glycerol at a concentration of 50%. This solution is stable for a period of 12 months from the date of receipt.
Target
Background	Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
Tissue specificity	Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined.
Celluar localization	Endoplasmic reticulum;Plasma Membrane;
UniPort	Q9BPV8