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Rabbit Anti-PEVR1 Polyclonal Antibody#abs135443

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Description

Catalog-specification	Delivery time	USD price
abs135443-100ug	1-2 Weeks	301.0
abs135443-50ug	1-2 Weeks	201.0

Overview
catalog	abs135443
Other names	The protein known as GPR172A, also referred to as hRFT3 or RFT3, is a riboflavin transporter 3 that plays a crucial role in the body's ability to absorb this important nutrient. Additionally, GPR172A has been identified as the receptor for porcine endogenous retrovirus A (PERV-A), which is a type of virus that can infect and cause disease in pigs and potentially humans. Due to its role in both riboflavin absorption and virus entry, GPR172A has garnered significant scientific interest and study. It is important to further investigate this protein and its potential implications for human health.
Source	Rabbit
Specificity	The PEVR1 antibody is capable of detecting the complete levels of endogenous PEVR1.
Species Reactivity	Human
Antigen	PEVR1
Application	To obtain optimal results, a WB dilution of 1:500 to 1:1000 is recommended. For IF/ICC, a dilution of 1:100 to 1:500 is suggested. When performing ELISA with a peptide substrate, a dilution of 1:20000 to 1:40000 is recommended for the best outcome. It is crucial to follow these dilution guidelines for accurate and reliable results.
Immunogen	A synthesized peptide.
MW	46 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography. Let me rephrase it for you: The purification process involved the application of SulfoLink™ Coupling Resin in order to conduct peptide affinity chromatography for the isolation of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the stability and efficacy of the product, it is advisable to store it at a temperature of -20 °C for a period of one year. To prevent any damage or alteration, it is important to avoid exposing the product to repeated freeze/thaw cycles. Take precautions to ensure the product is stored in a cool and dry environment to maintain its quality.
Storage buffer	Our Rabbit IgG comes in a solution of phosphate buffered saline, with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. To ensure its longevity, it can be stored at -20 °C and remains stable for up to a year from the date of receipt.
Target
Background	The transport of riboflavin is not dependent on sodium and exhibits moderate sensitivity to changes in pH. Interestingly, the activity of the riboflavin transporter can be strongly hindered by riboflavin analogs, specifically lumiflavin. Flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) also have a weak inhibitory effect on this transporter. Notably, during retroviral infections, the riboflavin transporter can serve as a cell receptor for retroviral envelopes, resembling the porcine endogenous retrovirus (PERV-A).
Tissue specificity	Highly expressed in brain, fetal brain and salivary gland. Weakly expressed in other tissues.
Celluar localization	Plasma Membrane;
UniPort	Q9HAB3