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Rabbit Anti-RRM2 Polyclonal Antibody#abs136760

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Description

Catalog-specification	Delivery time	USD price
abs136760-50ug	1-2 Weeks	201.0
abs136760-100ug	1-2 Weeks	301.0

Overview
catalog	abs136760
Description	The ribonucleotide reductase M2 subunit plays a crucial role in DNA synthesis and repair, as it is one of the two subunits that make up the ribonucleotide reductase enzyme. This enzyme is responsible for converting ribonucleotide 5'-diphosphates into 2'-deoxyribonucleotides, which are essential for the production of 2'-deoxyribonucleoside 5'-diphosphates (dNTPs), a necessary component for DNA synthesis and repair. RRM2 is only expressed during the late G1/early S phase of the cell cycle, and it is degraded in the late S phase. The activity of ribonucleotide reductase, and therefore DNA synthesis and cell proliferation, is controlled during the cell cycle by the synthesis and degradation of the RRM2 subunit. In summary, the ribonucleotide reductase M2 subunit is a vital component in the production of dNTPs required for DNA synthesis and repair. Its expression is tightly controlled during the cell cycle, and its activity is essential for proper cell proliferation and DNA maintenance.
Other names	There are several variants of the ribonucleotide reductase M2 subunit, including variant 1, variant 2, and variants 3a through 3d. This protein is also known as the ribonucleotide reductase small subunit, the ribonucleotide reductase regulatory subunit M2, and the ribonucleotide reductase protein r2 class I. Additionally, it is sometimes referred to as the Ribonucleotide reductase M2 polypeptide or the Ribonucleotide reductase small chain. The ribonucleotide reductase M2 subunit plays a crucial role in DNA replication and repair. It is responsible for converting ribonucleotides to deoxyribonucleotides, which are used to build DNA strands. Mutations in the gene encoding this protein can lead to various forms of cancer and other diseases. Other names for this protein include Ribonucleotide reductase, R2 subunit, RIR2_HUMAN, RR2, RR2M, and RRM2. It is an essential component of the ribonucleotide reductase enzyme complex, which also includes the ribonucleotide reductase M1 subunit. Together, these subunits work to ensure the proper formation of DNA and prevent genetic mutations that can lead to disease.
Source	Rabbit
Specificity	The RRM2 Antibody is capable of identifying natural levels of total RRM2 within a biological system. By utilizing this antibody, researchers can accurately determine the presence and quantity of RRM2.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Horse;Bovine;
Antigen	RRM2
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: - WB: 1:500-1:2000 - IHC: 1:50-1:200 - ELISA (peptide): 1:20000-1:40000.
Immunogen	A synthesized peptide derived from human RRM2.
MW	45kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLinkâ„¢ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Posttranslational modification	Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling.
Celluar localization	Cytosol;
UniPort	P31350