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Rabbit Anti-MYBPC3 Polyclonal Antibody#abs137540

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Description

Catalog-specification	Delivery time	USD price
abs137540-100ug	1-2 Weeks	301.0
abs137540-50ug	1-2 Weeks	201.0

Overview
catalog	abs137540
Other names	Cardiac muscle isoform C protein, also known as C-protein, is an important component of the cardiac muscle. It plays a crucial role in regulating the contraction and relaxation of the heart muscle. Known as cardiac MyBP-C or cardiac-type Myosin binding protein C, it is encoded by the MYBPC3 gene. The Myosin binding protein C cardiac type, or cardiac MyBP-C, is specifically expressed in the heart muscle and is vital for its proper function. It interacts with myosin and other structural proteins in the cardiac sarcomere, the basic unit of muscle contraction. This interaction helps to stabilize the sarcomere and modulate the contractile properties of the cardiac muscle. MYBPC3 is the gene that provides instructions for making the cardiac isoform of the Myosin binding protein C. Mutations in this gene can lead to cardiomyopathies, which are disorders of the heart muscle. These mutations disrupt the normal structure and function of the Myosin binding protein C, resulting in impaired contraction and relaxation of the heart muscle. This can lead to various cardiac conditions, including hypertrophic cardiomyopathy. In summary, the cardiac isoform of Myosin binding protein C, known as C-protein or cardiac MyBP-C, is an essential component of the heart muscle. It is encoded by the MYBPC3 gene and plays a crucial role in regulating the contraction and relaxation of the cardiac muscle. Mutations in the MYBPC3 gene can lead to cardiac disorders, highlighting the significance of this protein for proper heart function.
Source	Rabbit
Specificity	Endogenous levels of total MYBPC3 can be accurately detected using MYBPC3 Antibody. A content similar to the original text could be arranged as follows: The presence of total MYBPC3 can be effectively identified by utilizing MYBPC3 Antibody, which has the ability to detect endogenous levels.
Species Reactivity	Human
Antigen	MYBPC3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MYBPC3.
MW	150 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum. The process resulted in a highly purified product, which was free of any impurities. The chromatographic technique utilized the affinity of the antiserum to specific peptides, enabling selective binding and purification of the desired protein. The resulting purified product was highly efficient and suitable for a wide range of applications.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles as this can compromise its integrity. Taking these precautions will help to ensure that the product remains stable and effective for its intended use.
Storage buffer	The rabbit IgG is suspended in a solution of phosphate buffered saline, with a pH of 7.4, along with 150mM of NaCl, 0.02% sodium azide and 50% glycerol. It is recommended that the solution be stored at a temperature of -20 °C, where it will remain stable for up to 12 months from the date of its receipt. It is crucial to ensure that the generated content represents the original text, while producing a unique and relevant perspective.
Target
Background	Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Posttranslational modification	Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction (By similarity).Polyubiquitinated.
Celluar localization	Cytoskeleton;Cytosol;
UniPort	Q14896