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Rabbit Anti-WNT2 Polyclonal Antibody#abs137544

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Description

Catalog-specification	Delivery time	USD price
abs137544-100ug	1-2 Weeks	301.0
abs137544-50ug	1-2 Weeks	201.0

Overview
catalog	abs137544
Other names	Int-1-like protein 1, also known as INT1L1 or IRP, is a secreted growth factor that belongs to the Wingless type MMTV integration site family member 2. It shares a high degree of similarity with the Int 1-related protein, and both proteins are known to have oncogenic properties. IRP protein plays a crucial role in developmental processes and cellular signaling pathways, particularly in the regulation of cell proliferation and differentiation. It acts as a ligand for the Frizzled family of cell surface receptors, activating the canonical Wnt signaling pathway. Recent studies have shown that mutations in WNT2, the gene encoding Wnt-2 protein, are associated with several developmental disorders, including autism and dyslexia. WNT2 is also known to be involved in the pathogenesis of various cancers, including breast and lung cancer. Overall, the Int-1-like protein 1 and Wnt-2 are key players in many essential biological processes, and their dysregulation is implicated in numerous human diseases. Further research is needed to fully understand their roles in normal physiology and disease pathogenesis.
Source	Rabbit
Specificity	The WNT2 Antibody can accurately identify total WNT2 at its natural levels within the body. The antibody is designed to specifically target and detect this protein, allowing researchers and medical professionals to gain deeper insights into its role and functions. By rearranging the original content, this statement emphasizes the accuracy and precision of the antibody in detecting WNT2 levels in a natural environment.
Species Reactivity	Human;Rat
Predictive reaction species	Rabbit;Sheep;Dog;Bovine;Horse
Antigen	WNT2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human WNT2.
MW	40 kDa
Properties
Concentration	1mg/ml
purification	By employing SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification.
Clonality	Polyclonal Antibody
Stability & Storage	Store at a temperature of -20 °C for a duration of one year, ensuring that it does not undergo repeated freeze and thaw cycles.
Storage buffer	This Rabbit IgG is stored in phosphate buffered saline at a pH of 7.4, with a concentration of 150mM NaCl and 0.02% sodium azide, and it contains 50% glycerol. It should be kept at a temperature of -20 °C and can be safely stored for up to 12 months from the date of receipt.
Target
Background	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Tissue specificity	Expressed in brain in the thalamus, in fetal and adult lung and in placenta.
Posttranslational modification	Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
Celluar localization	Extracellular region or secreted;
UniPort	P09544