Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-FPRL1 Polyclonal Antibody#abs133098

Please note that the mentioned price is only for your reference. For detailed pricing information, kindly contact our seller, Vecent. It is essential to discuss directly with Vecent for accurate pricing details. Western blot analysis of FPRL1 expression in Extracts from HL60 cells.;,The lane on...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs133098-100ug	1-2 Weeks	301.0
abs133098-50ug	1-2 Weeks	201.0

Overview
catalog	abs133098
Description	The low affinity receptor for N-formyl-methionyl peptides is an important target in the regulation of neutrophil response to inflammatory stimuli. These peptides are potent neutrophil chemotactic factors that can activate the immune response via G-protein-coupled receptors. Specifically, binding of FMLP to the receptor leads to activation of neutrophils by triggering a phosphatidylinositol-calcium second messenger system. Interestingly, activation of LXA4R may result in an anti-inflammatory response that opposes the effects of proinflammatory signals such as LTB4. Therefore, understanding the mechanisms of action of these receptors could have important implications for the development of novel therapeutics for treating inflammatory diseases.
Other names	Formyl peptide receptor 2 (FPR2), also known as FMLP-R-I or FMLP-related receptor I, is a protein encoded by the ALXR gene. It is a member of the formyl peptide receptor family and is closely related to Formyl peptide receptor-like 1 (FMLP-R-II) and Formyl peptide receptor related (FMLPX). Other aliases for FPR2 include FPR2A, FPRH1, FPRH2, FPRL1, HM63, LXA4 receptor, and N-formyl peptide receptor 2. FPR2 plays a crucial role in mediating responses to formyl peptides, which are small peptides released by bacteria or damaged tissues during infection or injury. These formyl peptides activate FPR2, triggering various intracellular signaling pathways. As a result, FPR2 is involved in important biological processes, including chemotaxis, inflammation, immune response modulation, and tissue repair. Furthermore, FPR2 serves as the receptor for Lipoxin A4 (LXA4), an anti-inflammatory lipid molecule generated during the resolution phase of inflammation. Binding of LXA4 to FPR2 initiates signaling cascades that lead to the suppression of pro-inflammatory responses and facilitate the resolution of inflammation. Understanding the functions and mechanisms of FPR2 and its ligands holds significant therapeutic potential. Modulating FPR2 activation may provide new treatment strategies for inflammatory diseases, such as asthma, arthritis, and inflammatory bowel disease. Additionally, targeting FPR2 could potentially offer novel approaches to enhance the body's defense against bacterial infections. In conclusion, Formyl peptide receptor 2 (FPR2) and its various aliases play essential roles in mediating responses to formyl peptides and Lipoxin A4. Further research on FPR2 and its ligands may lead to the development of innovative therapies for inflammatory disorders and the enhancement of the immune system's ability to combat bacterial infections.
Source	Rabbit
Specificity	The levels of total FPRL1, an endogenous protein, can be detected using the FPRL1 antibody.
Species Reactivity	Human;Mouse
Antigen	FPRL1
Application	To get optimal results, we recommend diluting the primary antibody at a range of 1:500 - 1:2000 when using it for Western blot applications. For immunohistochemistry experiments, dilution at a range of 1:50 - 1:200 is advised. As for ELISA tests utilizing peptides, the primary antibody should be diluted at a range of 1:20,000 - 1:40,000. Using appropriate antibody dilutions can ensure accurate and reliable results in your experiments.
Immunogen	A synthesized peptide.
MW	38 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).
Tissue specificity	Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.
Celluar localization	Plasma Membrane;
UniPort	P25090