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Rabbit Anti-CYP4F2 Polyclonal Antibody#abs140405

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Description

Catalog-specification	Delivery time	USD price
abs140405-100ug	1-2 Weeks	301.0
abs140405-50ug	1-2 Weeks	201.0

Overview
catalog	abs140405
Other names	Cytochrome P450 LTB omega, also known as CYP4F14 or CYP1VF1, belongs to the family 4, subfamily F, polypeptide 2 of cytochrome P450 enzymes. It is an enzyme with the EC number 1.14.14.1. CYP4F14 plays a crucial role in the metabolism of leukotriene B(4), acting as both a monooxygenase and a hydroxylase. It is also known as leukotriene B(4) 20 monooxygenase and leukotriene B(4) omega hydroxylase. The gene encoding CYP4F14 is referred to as MGC126966 or MGC93476, and it is also known as P450 A3. This rearranged content provides an overview of CYP4F14 and its various names and functions based on the original information.
Source	Rabbit
Specificity	The detection of endogenous levels of total CYP4F2 is achieved using the CYP4F2 Antibody. Its primary function is to identify the presence of CYP4F2, ensuring accurate measurements. Rearranging the information from the original text, the antibody is designed specifically to recognize and bind to endogenous CYP4F2 levels. Its targeted detection aids in the quantification and analysis of CYP4F2 expression in various biological samples.
Species Reactivity	Human
Antigen	CYP4F2
Application	WB 1:1000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CYP4F2.
MW	60kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year without subjecting it to repeated freeze/thaw cycles. It is crucial to avoid any instances of freezing and thawing in order to maintain the integrity of the stored item.
Storage buffer	This product is comprised of rabbit IgG dissolved in a solution of phosphate buffered saline, pH 7.4, 150mM NaCl, and 0.02% sodium azide. Additionally, it contains 50% glycerol and should be stored at a temperature of -20 °C. This product is stable for up to one year after the date of receipt.
Target
Background	Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B4 omega-hydroxylase by mediating conversion of leukotriene-B4 (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene-B4 (20-OH LTB4) (PubMed:8026587, PubMed:9799565).
Tissue specificity	Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572).
Celluar localization	Endoplasmic reticulum;Plasma Membrane;
UniPort	P78329