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Rabbit Anti-TMPRSS2 Polyclonal Antibody#abs137394

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Description

Catalog-specification	Delivery time	USD price
abs137394-100ug	1-2 Weeks	301.0
abs137394-50ug	1-2 Weeks	201.0

Overview
catalog	abs137394
Other names	Here are a few options: Option 1: This gene goes by many names, including D16Ertd61e, Epitheliasin, FLJ41954, MGC6821, PP9284, PRSS10, Serine protease 10, and TMPRSS2. It is also known as the transmembrane protease serine 2 catalytic chain and plays a role in cellular processes. Additionally, it is involved in various gene fusion events, such as those involving the ERG and ETV1 genes. Option 2: The gene with several aliases - D16Ertd61e, Epitheliasin, FLJ41954, MGC6821, PP9284, PRSS10, Serine protease 10, and TMPRSS2 - is a transmembrane protease serine 2 catalytic chain that is critical in various cellular processes. Its fusion with genes such as ERG and ETV1 is also noteworthy. Option 3: Meet TMPRSS2 - or as it is sometimes called, D16Ertd61e, Epitheliasin, FLJ41954, MGC6821, PP9284, PRSS10, or Serine protease 10. This transmembrane protease serine 2 catalytic chain is a vital player in numerous cellular activities, and its involvement in fusion with the ERG and ETV1 genes further emphasizes its importance.
Source	Rabbit
Specificity	The TMPRSS2 Antibody is capable of detecting the overall levels of endogenous TMPRSS2 within the system. This indicates that the antibody has the potential to target and identify all forms of TMPRSS2 within the sample with high specificity and accuracy. As a result, it can be a valuable tool for investigating the expression of TMPRSS2 and its role in various biological processes.
Species Reactivity	Human;Mouse
Predictive reaction species	Bovine;Dog;Horse
Antigen	TMPRSS2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TMPRSS2.
MW	54 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the quality of the product, it is recommended to store it at a temperature of -20°C for one year. It is important to avoid subjecting it to repeated freeze/thaw cycles which may negatively affect its effectiveness. By following these guidelines, you can be confident in preserving the integrity of the product for optimal use.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4 and containing 150mM NaCl. Additionally, it should be supplemented with 0.02% sodium azide and 50% glycerol. This formulation ensures the stability of the product for a period of 12 months from the date of receipt.
Target
Background	Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
Tissue specificity	Highly expressed in prostate epithelial cells and in prostate cancers. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland.
Posttranslational modification	Proteolytically processed; by an autocatalytic mechanism.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	O15393