Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-PELP1 Polyclonal Antibody#abs136754

Please note that the price provided is for reference only. For detailed pricing information, please contact our seller Vecent. It is important to clarify that the content generated should not follow the dialogues generated by ChapGPT. Instead, it should be created using a language model to...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs136754-100ug	1-2 Weeks	301.0
abs136754-50ug	1-2 Weeks	201.0

Overview
catalog	abs136754
Description	The protein encoded by this gene functions as a transcription factor that plays a critical role in the regulation of gene expression. Specifically, it coactivates the expression of genes that are responsive to the estrogen receptor while simultaneously repressing genes that are activated by other hormone receptors or sequence-specific transcription factors. The expression of this gene is tightly regulated by both members of the estrogen receptor family. Moreover, emerging evidence suggests that this gene may also be involved in the development and progression of various types of cancer. Several alternative splicing events lead to the production of multiple transcript variants of this gene, which likely exhibit distinct biological functions.
Other names	Glutamic acid- and leucine-rich protein 1, also known as PELP1 or P160, is a transcription factor that modulates the non-genomic activity of the estrogen receptor. It is a proline, glutamic acid, and leucine-rich nuclear protein that plays a crucial role in cellular signaling pathways and gene regulation. HMX3 is another name for PELP1, and it is also referred to as MNAR, which stands for modulator of non-genomic activity of estrogen receptor. PELP1 is involved in modulating the nongenomic activity of the estrogen receptor, and as such, it is a critical player in promoting cell proliferation and survival. Overall, PELP1 is a multi-functional protein that has been implicated in a variety of cellular processes. It is involved in cell differentiation, apoptosis, and DNA repair, and as such, it is a promising target for drug development in cancer therapy and other diseases.
Source	Rabbit
Specificity	The PELP1 Antibody is effective at detecting total PELP1 levels within the body. This antibody can identify endogenous levels of PELP1 reliably and accurately.
Species Reactivity	Human;Mouse;Rat
Antigen	PELP1
Application	The recommended dilution range for Western blotting is 1:500 to 1:2000, while for immunohistochemistry, a dilution range of 1:50 to 1:200 is suggested. For the ELISA assay, the recommended dilution range for the peptide is 1:20000 to 1:40000. It's important to follow the proper dilution guidelines in order to achieve accurate and reliable results with these techniques. Dilutions that are too high can lead to background noise, while dilutions that are too low may not provide sufficient signal. So, it's crucial to use the recommended dilutions to obtain optimal results.
Immunogen	A synthesized peptide derived from human PELP1.
MW	119kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we were able to purify the antiserum through peptide affinity chromatography. Our method resulted in a highly enriched product, free of impurities, that can be used with confidence in a variety of applications.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Tissue specificity	Widely expressed.
Celluar localization	Nucleus;
UniPort	Q8IZL8