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Rabbit Anti-SCRN2 Polyclonal Antibody#abs135857

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Description

Catalog-specification	Delivery time	USD price
abs135857-100ug	1-2 Weeks	301.0
abs135857-50ug	1-2 Weeks	201.0

Overview
catalog	abs135857
Description	SCRN2 (secernin-2) is a peptidase C69 family protein consisting of 425 amino acids. It is one of the three paralogs present in the SCRN (Secernin) gene family, the other two being SCRN1 and SCRN3. Interestingly, each of these paralogs is closely associated with a specific cluster in the human genome. SCRN1 is linked to the HOXA cluster, SCRN2 to the HOXB cluster, and SCRN3 to the HOXD cluster. The topology of vertebrate SCRN genes follows the pattern (A)(BC), with SCRN2 falling outside the SCRN3–SCRN1 cluster. In the case of humans, SCRN2 is located on chromosome 17q21.32. Chromosome 17 is quite substantial, comprising more than 2.5% of the human genome. It spans approximately 81 million bases and contains over 1,200 genes. It is worth noting that chromosome 17 is associated with various genetic disorders. Neurofibromatosis, a condition characterized by the development of neural and epidermal lesions along with abnormal growth of Schwann cells, is one such disorder. Additionally, chromosome 17 is also linked to Alexander disease, Birt-Hogg-Dube syndrome, and Canavan disease. Across different species, including dog, cow, mouse, rat, and zebrafish, the SCRN2 gene remains conserved, implying its importance in biological processes shared among vertebrates. Hence, SCRN2 and its associated gene family play significant roles in various aspects of vertebrate development and physiology.
Other names	scrn2; SCRN2_HUMAN; Secernin 2; Secernin-2; Ses2;
Source	Rabbit
Specificity	Endogenous levels of total SCRN2 can be detected using the SCRN2 Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	SCRN2
Application	For Western blotting, dilute the primary antibody at a range of 1:500 to 1:2000. For immunohistochemistry, the recommended dilution of the primary antibody is between 1:50 and 1:200. In case of immunofluorescence and immunocytochemistry, we suggest a dilution range of 1:100-1:500. For ELISA (peptide), we recommend a dilution of 1:20000-1:40000. Please note that these dilution ranges are based on the original information provided and should be followed accordingly for optimum results.
Immunogen	A synthesized peptide derived from human SCRN2.
MW	47kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Celluar localization	Extracellular region or secreted;
UniPort	Q96FV2