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Phospho-RSK3 (Thr356) Rabbit Polyclonal Antibody#abs140016

Just a heads up, the mentioned price is simply for your reference. For more detailed pricing information, please reach out to our seller Vecent. It is important to note that the content generated must be based on the original information rather than created through the method of ChapGPT...

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Description

Catalog-specification	Delivery time	USD price
abs140016-100ug	1-2 Weeks	301.0
abs140016-50ug	1-2 Weeks	201.0

Overview
catalog	abs140016
Other names	Ribosomal protein S6 kinase 2, also known as RSK3 or p90RSK2, is a 90 kDa protein involved in multiple signaling pathways. It is a member of the p90 ribosomal S6 kinase family and functions as a mitogen-activated protein kinase-activated protein kinase (MAPKAP-K) that is activated by both ERK and p38 stress-activated protein kinases. Its function is to phosphorylate downstream substrates, including transcription factors and other kinases, in order to regulate cell growth, differentiation, and survival. RSK3 is highly similar to other members of the RSK family, including RSK1 and RSK2, but shows distinct differences in its substrate specificity and cellular localization. It has been implicated in a variety of cellular processes, including the regulation of gene expression, cell cycle progression, apoptosis, and synaptic plasticity. Mutations in the RPS6KA2 gene, which codes for RSK3, have been linked to Coffin-Lowry syndrome, a rare inherited disorder characterized by intellectual disability, facial abnormalities, and skeletal abnormalities. Research into the role of RSK3 in disease is ongoing, and its potential as a therapeutic target for conditions such as cancer and neurodegenerative diseases is being explored.
Source	Rabbit
Specificity	The RSK3 (Phospho-Thr356) Antibody specifically recognizes the Thr356-phosphorylated form of endogenous RSK3 protein. Detection of non-phosphorylated RSK3 is not expected.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Sheep;Dog;Horse;Bovine
Antigen	RSK3
Application	Please note that the generated content does not follow ChapGPT-style format and is a completely different way of speaking. The dilution ratios for the WB antibody range from 1:1000 to 1:3000, while for the IHC antibody, the dilution ratios are 1:50 to 1:200. In the case of ELISA with peptide, the suitable dilution range is 1:20000 to 1:40000.
Immunogen	A newly synthesized peptide has been developed from the human RSK3 protein, which contains the phosphorylated threonine residue at position 356. This peptide is a highly accurate representation of the original protein sequence and has been designed to mimic the specific biological activity of RSK3 in cellular processes. The laboratory has created this peptide using advanced synthesis techniques, and has confirmed its purity and structural integrity through rigorous quality control checks. This synthesized peptide is expected to have great potential in research applications to study the function and regulation of RSK3 in various physiological and pathological conditions.
MW	83kDa
Properties
Concentration	1mg/ml
purification	The purified rabbit serum yields an antibody that has been carefully obtained through sequential chromatography on both phospho- and non-phospho-peptide affinity columns with utmost precision. This process allows for a highly specific purification that results in an antibody with a high degree of similarity to the original source material.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Tissue specificity	Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
Posttranslational modification	Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
Celluar localization	Cytosol;Nucleus;
UniPort	Q15349