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Rabbit Anti-CLPP Polyclonal Antibody#abs137925

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Description

Catalog-specification	Delivery time	USD price
abs137925-100ug	1-2 Weeks	301.0
abs137925-50ug	1-2 Weeks	201.0

Overview
catalog	abs137925
Other names	The proteolytic subunit of E. coli ATP-dependent protease ClpAP, also known as ClpP, is an important protein involved in protein degradation. It is also found in humans and is referred to as the ATP-dependent proteolytic subunit homolog. Additionally, it is known as the caseinolytic peptidase ATP-dependent proteolytic subunit. The homologous forms of this subunit, such as the Caseinolytic peptidase ATP-dependent proteolytic subunit homolog, are present in various organisms. In E. coli, it acts as the ATP-dependent proteolytic subunit of the ClpAP protease. It is believed to have a similar function in other organisms as well. In humans, the protein is referred to as CLPP_HUMAN and is found in the mitochondrial compartment. It is considered a putative ATP-dependent Clp protease proteolytic subunit. This suggests that it might play a role in protein degradation within the mitochondria. Overall, the ATP-dependent proteolytic subunit ClpP, in its various forms and homologs, is a crucial component of the protein degradation machinery in different organisms. It serves as an endopeptidase and is involved in maintaining protein homeostasis by eliminating misfolded or damaged proteins.
Source	Rabbit
Specificity	The CLPP Antibody is capable of identifying total CLPP levels present within the body naturally. To create similar content, one could rearrange the original text to say: The detection levels of endogenous total CLPP can be determined using the CLPP Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Zebrafish;Rabbit;Pig;Dog;Horse;Bovine;Sheep;
Antigen	CLPP
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CLPP.
MW	30 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography. The resulting product is highly purified and ready for use.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
Tissue specificity	Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.
Celluar localization	Mitochondrion;
UniPort	Q16740