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Rabbit Anti-GSC2 Polyclonal Antibody#abs133320

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Description

Catalog-specification	Delivery time	USD price
abs133320-100ug	1-2 Weeks	301.0
abs133320-50ug	1-2 Weeks	201.0

Overview
catalog	abs133320
Other names	Goosecoid 2 (GSC 2) and Goosecoid-like (GSCL) are homeobox proteins that play important roles in development. These proteins are highly similar and share many functions with each other. They both belong to the Goosecoid family of transcription factors that regulate gene expression in various tissues and organs. GSC 2 and GSCL are involved in the formation and patterning of the embryonic axis, especially in the head and trunk regions. They also contribute to the differentiation of various cell types, including neural, muscle, and cartilage cells. In addition, these homeobox proteins have been implicated in the development of the digestive, respiratory, and urogenital systems. Although GSC 2 and GSCL have some functional differences, their structural similarities suggest that they may have overlapping roles in development. Further research is needed to fully understand the mechanisms by which these proteins regulate gene expression and cell differentiation. Nonetheless, their importance in embryonic development and disease pathogenesis makes them promising targets for therapeutic interventions.
Source	Rabbit
Specificity	The endogenous levels of total GSC2 can be detected using the GSC2 Antibody.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Bovine;
Antigen	GSC2
Application	The dilution ranges for WB (Western Blot) are 1:1000-3000, for IF/ICC (Immunofluorescence/Immunocytochemistry) are 1:100-1:500, and for ELISA (Enzyme-Linked Immunosorbent Assay) using a peptide are 1:20000-1:40000. These dilutions are commonly used in biological experiments to achieve optimal detection of target proteins. The dilution ratio determines the concentration of the primary antibody, which should ideally strike a balance between sensitivity and specificity. It is crucial to optimize the dilution factor for each antibody and experimental condition to obtain reliable and reproducible results.
Immunogen	A synthesized peptide derived from human GSC2.
MW	25 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimum quality, it is recommended to store the product at a temperature of -20°C for a period of one year. It is important to avoid exposing the product to repeated cycles of freezing and thawing as this can lead to degradation of the product over time. By following these simple storage guidelines, you can be confident in the stability and effectiveness of the product throughout its recommended shelf life.
Storage buffer	This Rabbit IgG solution is suspended in phosphate buffered saline with pH 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at -20°C, and it is stable for up to 12 months from the date of receipt.
Target
Background	May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC.
Tissue specificity	Detected in adult testis and pituitary, and in 9-10 week fetal tissue (thorax). Probably expressed in other tissues at low levels.
Celluar localization	Nucleus;
UniPort	O15499