Rabbit Anti-GluR4 Polyclonal Antibody#abs131562
Please note that the price mentioned above is only for your reference and for detailed pricing information, we request you to get in touch with our seller Vecent. This will help you get a better understanding of the price and other relevant information regarding your purchase. We encourage you...
Description
| Catalog-specification | Delivery time | USD price |
abs131562-100ug | 1-2 Weeks | 301.0 |
abs131562-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is only for your reference and for detailed pricing information, we request you to get in touch with our seller Vecent. This will help you get a better understanding of the price and other relevant information regarding your purchase. We encourage you to reach out to us for any queries or concerns you may have. Thank you for considering our product!
| Overview | |
catalog | abs131562 |
Description | The ionotropic glutamate receptor is responsible for the excitatory effects of L-glutamate as a neurotransmitter in the central nervous system. When L-glutamate binds to the receptor, it triggers a structural reconfiguration that enables the opening of the cation channel. This paves the way for the stimulation of neural circuits and the transmission of important messages throughout the brain. Overall, the ionotropic glutamate receptor plays a critical role in modulating the flow of neuronal information in the CNS. |
| Other names | Metabotropic glutamate receptor 4, also known as mGlu4 or GRM4, is a glutamate receptor belonging to the G protein-coupled receptor family. It is encoded by the GPRC1D gene in humans. Metabotropic glutamate receptors are a class of receptors that are involved in the modulation of synaptic transmission in the central nervous system. mGlu4 plays a crucial role in regulating synaptic activity by responding to the neurotransmitter glutamate. Unlike ionotropic glutamate receptors that mediate fast synaptic transmission, metabotropic glutamate receptors modulate slower and more sustained cellular responses through G protein signaling pathways. The metabotropic glutamate receptor 4 is widely expressed in various regions of the brain, including the hippocampus, cerebellum, and cortex. It functions as an autoreceptor, meaning that it is often found on presynaptic terminals and acts as a feedback regulator of glutamate release. Dysregulation of mGlu4 has been implicated in several neurological disorders, including epilepsy, Parkinson's disease, and schizophrenia. Therefore, understanding the role and function of this receptor is important for developing therapeutic interventions. In summary, the metabotropic glutamate receptor 4, encoded by the GPRC1D gene, is a key player in modulating synaptic transmission in the central nervous system. Its widespread distribution and involvement in various neurological disorders make it an intriguing target for further research and potential therapeutic interventions. |
| Source | Rabbit |
| Specificity | The GluR4 Antibody is capable of identifying the total amount of GluR4 present in an organism's body naturally. It can detect the endogenous levels of this protein with great accuracy. To produce content that closely resembles the aforementioned text, the information can be rearranged and rephrased to indicate that the GluR4 Antibody is adept at detecting the complete quantity of GluR4 found in an organism. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | GluR4 |
| Application | For Western blot, the recommended dilutions are 1:500 to 1:2000. When performing immunohistochemistry, it is recommended to dilute the primary antibody at 1:50 to 1:200. If you are doing immunofluorescence or immunocytochemistry, the primary antibody should be diluted at 1:100 to 1:500. Lastly, for ELISA using a peptide, a dilution range of 1:20000 to 1:40000 is recommended. It's important to use the correct dilution for your experiment to ensure accurate and reliable results. |
| Immunogen | A synthesized peptide derived from human GluR4. |
| MW | 98 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLink™，。 |
| Clonality | Polyclonal Antibody |
| Stability & Storage | One year of storage at -20 °C is recommended. It is important to avoid subjecting the product to repeated freeze/thaw cycles. |
| Storage buffer | The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline solution with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of the Rabbit IgG is guaranteed for 12 months from the date of receipt. Please make sure to adhere to these storage guidelines to ensure the quality and longevity of the product. |
Target | |
Background | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. |
| Tissue specificity | Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver. |
| Celluar localization | Plasma Membrane; |
| UniPort | Q14833 |
This product is for research use only, not for use in diagnostic prodecures or in human.
Hot Tags: rabbit anti-glur4 polyclonal antibody#abs131562, China rabbit anti-glur4 polyclonal antibody#abs131562 suppliers
Send Inquiry
You Might Also Like
