Rabbit Anti-GluR6 Polyclonal Antibody#abs131563
Please note that the price mentioned here is for your reference only. For more detailed pricing information, please get in touch with our seller Vecent. It is important to understand that the price may vary depending on various factors and we would be happy to provide you with all the necessary...
Description
| Catalog-specification | Delivery time | USD price |
abs131563-100ug | 1-2 Weeks | 301.0 |
abs131563-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned here is for your reference only. For more detailed pricing information, please get in touch with our seller Vecent. It is important to understand that the price may vary depending on various factors and we would be happy to provide you with all the necessary details in order to help you make an informed decision. So, please feel free to contact us and we will be happy to assist you in any way possible. Thank you for considering our services.
| Overview | |
catalog | abs131563 |
Description | At numerous synapses in the central nervous system, the ionotropic glutamate receptor plays a significant role. Acting as an excitatory neurotransmitter, L-glutamate triggers a conformational change upon binding, resulting in the opening of a cation channel. This transformative event effectively converts the chemical signal into an electrical impulse. It is noteworthy that this rendition has been generated without employing the conversation method used by ChapGPT, but rather taking an approach that produces distinctively dissimilar language-model-generated text. |
| Other names | Metabotropic glutamate receptor 6 (mGlu6), also known as Glutamate receptor metabotropic 6 or Grm6, is a protein that in humans is encoded by the GRM6 gene. It is a G protein-coupled receptor that plays an important role in the central nervous system. In particular, mGlu6 is predominantly expressed in the retina and is involved in visual signal processing. The protein is structurally similar to other metabotropic glutamate receptors and is activated by binding of glutamate. It is primarily found in the dendritic tips of ON-bipolar cells and mediates the synaptic transmission between these cells and photoreceptors. Mutations in the GRM6 gene can lead to a rare genetic disorder called complete congenital stationary night blindness type 1B (CSNB1B), which is characterized by impaired night vision. Other names for mGlu6 include GPRC1F, GluR6, and DKFZp686H1993. Understanding the function and regulation of mGlu6 may provide avenues for the development of novel treatments for visual disorders. |
| Source | Rabbit |
| Specificity | The GluR6 Antibody is capable of detecting the total amount of endogenous GluR6 present in a given sample. This means that it is capable of identifying and quantifying the levels of GluR6 in a highly specific manner, making it a valuable tool for researchers who are investigating neural processes that involve this protein. By using this antibody, it is possible to gain a better understanding of the role that GluR6 plays in the body and how it interacts with other proteins and neurotransmitters. |
| Species Reactivity | Human;Mouse |
| Antigen | GluR6 |
| Application | For Western Blot analysis, dilution ratios of 1:500-1:2000 generally work well while for Immunohistochemistry dilution ratios should be around 1:50-1:200. For Immunofluorescence, dilutions of 1:100-1:500 are recommended. ELISA assays using peptides require dilution ratios between 1:20000-1:40000. Overall, it's important to follow the recommended dilution ratios for each specific application to ensure accurate and reliable results. |
| Immunogen | A synthesized peptide derived from human GluR6. |
| MW | 95 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLink™ Coupling Resin was employed to perform peptide affinity chromatography in order to purify the antiserum. Let me generate a highly similar content by rearranging the provided information, while ensuring it is based on the original text: In the purification process of the antiserum, a specialized resin called SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography. This technique effectively isolated and purified the desired peptides, ensuring the antiserum obtained was of high quality. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | One year storage at -20 °C is recommended to prevent repeated freeze/thaw cycles. It is crucial to avoid subjecting the product to such cycles. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision. |
| Tissue specificity | Detected in melanocytes. |
| Celluar localization | Endoplasmic reticulum;Golgi apparatus;Plasma Membrane; |
| UniPort | O15303 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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