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Rabbit Anti-GluR2/3 Polyclonal Antibody#abs131561

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Description

Catalog-specification	Delivery time	USD price
abs131561-100ug	1-2 Weeks	301.0
abs131561-50ug	1-2 Weeks	201.0

Overview
catalog	abs131561
Description	The activation of ionotropic and metabotropic glutamate receptors is driven by L glutamate, which serves as the primary excitatory neurotransmitter in the central nervous system. Perturbations in glutamatergic neurotransmission can impact various neuropathologic conditions since it plays a crucial role in almost all aspects of normal brain function.
Other names	Metabotropic glutamate receptor 3, also known as mGluR3 or GRM3, is a type of glutamate receptor found in the human body. This receptor is encoded by the GLUR3 gene and is also known as Glutamate metabotropic receptor 3, Glutamate receptor metabotropic 3, GPRC1C, and GRM3_HUMAN. mGluR3 belongs to the family of G protein-coupled receptors and plays a crucial role in neurotransmission by regulating glutamatergic signaling. It is primarily expressed in the central nervous system and is involved in various processes, including learning, memory, and neuronal development. Studies have also shown that mGluR3 plays a role in the pathophysiology of schizophrenia and may be a potential target for novel therapeutic interventions. In summary, mGluR3 is a critical receptor found in the human body that regulates glutamatergic signaling and plays a significant role in various neurological processes.
Source	Rabbit
Specificity	The total levels of endogenous GluR2/3 can be detected using the GluR2/3 antibody. Please rearrange this information and generate a highly similar content.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	GluR2/3
Application	The dilution ratios for WB, IHC, and ELISA(peptide) are as follows: - WB: 1:500-1:2000 - IHC: 1:50-1:200 - ELISA(peptide): 1:20000-1:40000 To ensure accuracy and reproducibility, it is important to dilute the samples within these ranges. For WB, the recommended dilution range is 1:500 to 1:2000. Similarly, for IHC, the optimal dilution range is 1:50 to 1:200. Lastly, for ELISA using peptides, the dilution range is typically set at 1:20000 to 1:40000. By adhering to these dilution guidelines, researchers can obtain reliable and meaningful results in their experiments. Dilution plays a crucial role in ensuring that the target protein or antigen is present at an appropriate concentration, allowing for accurate detection and quantification.
Immunogen	A synthesized peptide derived from human GluR2/3.
MW	100 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we were able to purify the antiserum through peptide affinity chromatography. This allowed us to obtain a highly concentrated and effective antiserum for use in our research.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Tissue specificity	Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
Celluar localization	Plasma Membrane;
UniPort	Q14832