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Rabbit Anti-NPC1L1 Polyclonal Antibody#abs137926

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Description

Catalog-specification	Delivery time	USD price
abs137926-100ug	1-2 Weeks	301.0
abs137926-50ug	1-2 Weeks	201.0

Overview
catalog	abs137926
Other names	Niemann-Pick C1-like protein 1, also known as NPC1-like 1 or NPC1L1, is a gene associated with Niemann-Pick disease type C1. This protein plays a crucial role in cholesterol absorption and transport. It is essential for the efficient uptake of dietary cholesterol from the intestine. NPC1L1 is also known for regulating the intracellular cholesterol trafficking process. Considering the rearranged content: Truncated Niemann Pick C1 like protein 1, also referred to as NPC1L1, NPC1L1 splice variant, or Niemann Pick disease type C1 gene like 1, is a crucial protein involved in cholesterol absorption and transport. Its primary function is to facilitate the efficient intake of dietary cholesterol from the intestine. Additionally, NPC1L1 plays a significant role in regulating intracellular cholesterol trafficking, which contributes to maintaining cholesterol homeostasis within cells. With its important role in cholesterol metabolism, NPC1L1 serves as a potential therapeutic target for disorders associated with impaired cholesterol transport.
Source	Rabbit
Specificity	The total levels of endogenous NPC1L1 can be detected with the NPC1L1 antibody.
Species Reactivity	Human
Predictive reaction species	Pig;Horse;
Antigen	NPC1L1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human NPC1L1.
MW	149 kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the antiserum was refined through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for up to a year. It is important to note that repeated cycles of freezing and thawing should be avoided in order to preserve the product's integrity.
Storage buffer	The Rabbit IgG is available in a formulation containing phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is recommended that the IgG be stored at -20 °C for optimal stability. The product is stable for a period of 12 months from the date of receipt. So, customers can safely use it for their experiments for up to 12 months after purchase.
Target
Background	Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Tissue specificity	Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
Posttranslational modification	Highly glycosylated.
Celluar localization	Plasma Membrane;
UniPort	Q9UHC9