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Rabbit Anti-IL1RL1 Polyclonal Antibody#abs132912

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Description

Catalog-specification	Delivery time	USD price
abs132912-100ug	1-2 Weeks	301.0
abs132912-50ug	1-2 Weeks	201.0

Overview
catalog	abs132912
Description	Stimulation of the interleukin-33 (IL-33) receptor leads to the recruitment of MYD88, IRAK1, IRAK4, and TRAF6. This recruitment is followed by the phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. The receptor's involvement in helper T-cell function is also a possibility. To create highly similar content based on the original information, the following rearranged version is generated: The recruitment of MYD88, IRAK1, IRAK4, and TRAF6 occurs upon stimulation of the interleukin-33 (IL-33) receptor. Subsequently, MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 undergo phosphorylation. The receptor may also play a role in helper T-cell function.
Other names	Interleukin-1 receptor like 1, also known as IL33R or ST2, is a protein expressed in humans that plays a key role in growth stimulation. It is the homolog of the mouse growth stimulation-expressed protein and is encoded by the gene DER4 or IL1RL1. In addition to its growth-promoting effects, IL1RL1 is also known as T1 protein and ST2V and functions as an interleukin-1 receptor related protein. Its expression is crucial for the proper functioning of the immune system, particularly in response to infections and inflammation. The precise mechanisms by which IL1RL1 exerts its effects are the subject of ongoing research, but it is thought to be involved in the regulation of cytokine production and immune cell activation. Overall, IL1RL1 is an important molecule with diverse roles in human biology.
Source	Rabbit
Specificity	The ST2 antibody is capable of identifying total ST2 levels that are naturally present within an organism.
Species Reactivity	Human;Mouse
Antigen	IL1RL1
Application	The recommended dilutions for WB are between 1:500 and 1:2000, while for IHC the range is 1:50 to 1:200. When using ELISA with peptide, a dilution of 1:20000 to 1:40000 is suggested. It is important to adhere to these dilution guidelines in order to achieve optimal results in experimental procedures. Be sure to handle the samples carefully and follow all safety precautions to ensure accuracy and reproducibility of the results.
Immunogen	A synthesized peptide derived from human ST2.
MW	70 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through the process of peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the integrity of the product, it is recommended to keep it frozen at -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles, as this can compromise its quality and efficacy.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.
Tissue specificity	Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q01638