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Rabbit Anti-OLIG1 Polyclonal Antibody#abs137896

Description

Catalog-specification	Delivery time	USD price
abs137896-100ug	1-2 Weeks	301.0
abs137896-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137896
Other names	The basic domain helix loop helix protein class B 6, also known as BHLH B6 or BHLHB 6, is a crucial transcription factor that plays a significant role in regulating various cellular processes. This protein is commonly referred to as Oligodendrocyte lineage transcription factor 1 or Olig1 due to its role in controlling the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. Additionally, Olig1 is involved in the maintenance and survival of oligodendrocytes, making it a vital component in the central nervous system. Furthermore, Olig1 belongs to the class B basic helix-loop-helix protein family, with another member being class E basic helix-loop-helix protein 21 or bHLHe21. Both proteins share a similar structure consisting of two domains, the basic domain, and the helix-loop-helix domain, which are essential for their function as transcription factors. Research has shown that the dysregulation of Olig1 can lead to various neuropathological conditions, such as multiple sclerosis and cerebral ischemia. Therefore, understanding the role of Olig1 in oligodendrocyte differentiation and function is critical in the development of therapies for these diseases. In summary, the basic domain helix loop helix protein class B 6 or Olig1 is a vital transcription factor involved in the regulation of oligodendrocyte development and function. Its dysregulation can lead to several neuropathological conditions, making it a potential target for therapeutic intervention.
Source	Rabbit
Specificity	The OLIG1 Antibody has the ability to recognize total OLIG1 present in natural proportions.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Pig;Dog;Bovine;
Antigen	OLIG1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human OLIG1.
MW	35 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we were able to purify the antiserum via peptide affinity chromatography. This resulted in a highly refined product that can be used for a variety of applications. Our purification process ensures that the antiserum is of the highest quality and purity, making it an excellent tool for researchers and scientists alike.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the material's quality, it is recommended to store it at a temperature of -20 °C for up to one year. It is crucial to avoid exposing the material to repeated freeze/thaw cycles, as this process could cause damage to its structure and properties. Therefore, it is essential to handle and store the material with care and follow the recommended storage conditions closely. Adhering to these guidelines will ensure that the material remains in optimal condition for its intended use.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).
Tissue specificity	Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
Celluar localization	Nucleus;
UniPort	Q8TAK6