Phospho-HIPK1/2/3 (Tyr352/361/359) Rabbit Polyclonal Antibody#abs139984
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Description
| Catalog-specification | Delivery time | USD price |
abs139984-100ug | 1-2 Weeks | 301.0 |
abs139984-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for reference purposes only. For more detailed pricing information, please contact our sales representative Vecent. It is important to emphasize that the content generated should be based on the original text information, but rearranged in a highly similar way that does not rely on ChapGPT-generated conversation. Instead, let's use language models to produce text that is significantly different from the generated content.
| Overview | |
catalog | abs139984 |
| Other names | There are several homeodomain interacting protein kinases that have been identified in humans, including Hipk1, Hipk2, and Hipk3. These kinases play an important role in a variety of cellular processes, including gene expression, cellular differentiation, and apoptosis. Hipk1, also known as nuclear body associated kinase 2 or Nbak2, is a protein kinase that is involved in the regulation of gene expression and the control of cell proliferation. It has been shown to interact with a number of transcription factors, including p53 and nuclear factor-kappa B (NF-κB). Hipk2, also known as sialophorin tail-associated nuclear serine/threonine-protein kinase or STANK, is a protein kinase that is involved in the regulation of cellular growth and differentiation. It has been shown to interact with a number of proteins, including the androgen receptor and Fas. Hipk3, also known as homolog of protein kinase YAK1 or PKY, is a protein kinase that is involved in the regulation of the cell cycle and apoptosis. It has been shown to interact with a number of proteins, including the tumor suppressor p53 and the transcription factor c-Myc. Overall, the homeodomain interacting protein kinases are important regulators of cellular processes, and their dysregulation has been implicated in a variety of human diseases, including cancer and neurodegenerative disorders. |
| Source | Rabbit |
| Specificity | The HIPK1/2/3 (Phospho-Tyr352/361/359) Antibody is specifically designed to detect the presence of HIPK1/2/3 proteins only when they are phosphorylated at their Tyr352/361/359 residues. This antibody is capable of identifying endogenous levels of HIPK1/2/3 proteins that exhibit this phosphorylation pattern. Its specificity ensures that other non-phosphorylated forms of HIPK1/2/3 are not detected by this antibody. Overall, this antibody is a valuable tool for investigating the functions and regulation of HIPK1/2/3 proteins in biological systems. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine |
| Antigen | HIPK1/2/3 |
| Application | ，。WB1:1000-3000，IHC1:50-1:200，ELISA（）1:20000-1:40000。 |
| Immunogen | HIPK1/2/3 (Phospho-Tyr352/361/359) is a human-derived synthesized peptide that has been developed. It is important to note that the content should not be generated using the method of ChapGPT's content generation. Instead, I will deliver the information using a completely different approach of text generation. |
| MW | 130KD |
| Properties | |
Concentration | 1mg/ml |
| purification | The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. |
| Tissue specificity | Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. |
| Posttranslational modification | Autophosphorylated. Phosphorylated and activated by JNK1.Degraded by PARK7 at the protein level.Sumoylated. When conjugated it is directed to nuclear speckles. SENP1-mediated desumoylation is mediated by TNF in response to stress stimuli, triggering transient translocation from nucleus to cytoplasm. |
| Celluar localization | Cytoskeleton;Cytosol;Nucleus; |
| UniPort | Q86Z02/Q9H2X6/Q9H422 |
Western blot analysis HIPK1/2/3 (Phospho-Tyr352/361/359) using TNF-α treated A2780 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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