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Rabbit Anti-JAKMIP2 Polyclonal Antibody#abs133695

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Description

Catalog-specification	Delivery time	USD price
abs133695-100ug	1-2 Weeks	301.0
abs133695-50ug	1-2 Weeks	201.0

Overview
catalog	abs133695
Other names	The CTCL tumor antigen HD-CL-04, also known as Jak and microtubule interacting protein 2 (JAKMIP2), Janus kinase and microtubule-interacting protein 2 (Janus kinase and microtubule interacting protein 2), or NECC1 (Neuroendocrine long coiled coil protein 1), is a key protein involved in the development of cutaneous T-cell lymphoma (CTCL). This protein plays a critical role in regulating cell growth and division, and its aberrant expression has been linked to cancer progression. JAKMIP2 is a large, multi-functional protein that interacts with microtubules, a key component of the cellular cytoskeleton that is involved in cell migration and division. By binding to microtubules, JAKMIP2 helps to regulate cell morphology and ensure proper cell division. Research has also suggested that JAKMIP2 may be involved in the regulation of immune responses, as well as neural development and function. Mutations in JAKMIP2 have been associated with certain neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. Overall, the study of JAKMIP2 and its various functions is still ongoing, but it is clear that this protein plays a critical role in many important cellular processes, and may be an important target for future therapeutic interventions.
Source	Rabbit
Specificity	The total levels of endogenous JAKMIP2 can be detected using the JAKMIP2 Antibody. To generate a highly similar content based on the original text information, we could rearrange the statement as follows: The JAKMIP2 Antibody is designed to specifically detect the endogenous levels of total JAKMIP2.
Species Reactivity	Human;Mouse
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	JAKMIP2
Application	For Western blotting, a dilution range of 1:500 to 1:1000 is recommended. Immunohistochemistry requires a dilution range of 1:50 to 1:200, while for immunofluorescence and immunocytochemistry, a dilution range of 1:100 to 1:500 is suggested. For ELISA assays using peptides, a dilution range of 1:20000 to 1:40000 is recommended. It is important to ensure that the dilution range used is appropriate for the specific application to obtain accurate and reliable results.
Immunogen	A synthesized peptide.
MW	95 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography was employed to purify the antiserum, utilizing SulfoLink™ Coupling Resin for the process.
Clonality	Polyclonal Antibody
Stability & Storage	One should store the product at -20°C for a period of one year to maintain its quality. It is important to avoid subjecting the product to repeated freeze/thaw cycles during storage.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Tissue specificity	Highly expressed in brain, moderately expressed in thymus, spleen and lung, and weakly expressed in kidney, liver and peripheral blood lymphocytes. Also expressed in adrenal and pituitary glands, as well as testis.
Celluar localization	Golgi apparatus;
UniPort	Q96AA8