Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-ISL2 Polyclonal Antibody#abs133694

Please note that the price provided is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. Kindly refrain from using ChapGPT to generate the content and instead, generate text using a completely different approach from the language model....

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs133694-100ug	1-2 Weeks	301.0
abs133694-50ug	1-2 Weeks	201.0

Overview
catalog	abs133694
Other names	ISL2, also known as Insulin gene enhancer protein ISL 2 or ISL-2, is a transcription factor that plays a significant role in gene regulation. It is encoded by the FLJ10160 gene and belongs to the ISL family of LIM-homeodomain transcription factors. ISL2 is involved in the regulation of insulin gene expression and is essential for correct pancreatic islet development and function. The ISL2 protein contains a LIM-homeodomain, which is a DNA-binding domain that allows it to interact with specific DNA sequences and control gene expression. It acts as a transcriptional activator, promoting the expression of target genes involved in pancreatic development and insulin production. Additionally, ISL2 is also known as Islet-2 or Islet2, reflecting its role in pancreatic islet formation. Dysfunction or mutations in the ISL2 gene have been implicated in pancreatic disorders and diabetes. In summary, ISL2 is a transcription factor that plays a crucial role in regulating the expression of genes involved in pancreatic development and insulin production. Its LIM-homeodomain allows it to bind to specific DNA sequences and activate gene transcription. Dysregulation of ISL2 can lead to pancreatic disorders and diabetes.
Source	Rabbit
Specificity	The total ISL2 can be identified using the ISL2 Antibody, which is capable of detecting the natural levels of endogenous ISL2 protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Pig;Sheep;Horse;Bovine
Antigen	ISL2
Application	For Western blotting, the suggested dilution range is 1:500 to 1:1000. When using immunofluorescence or immunocytochemistry, a dilution of 1:100 to 1:500 is recommended. For ELISA based on peptide antigen, the optimal dilution is 1:20,000 to 1:40,000. It is important to use the appropriate dilution to ensure accurate and reliable results in these assays.
Immunogen	A synthesized peptide.
MW	40 KD
Properties
Concentration	1mg/ml
purification	Our team purified the antiserum through a process of peptide affinity chromatography. We utilized SulfoLink™ Coupling Resin to ensure the efficiency of the purification process. This allowed us to produce a highly refined and concentrated antiserum product that is of exceptional quality. We took care to ensure that our method was reliable and trustworthy, so that our clients can rely on us for the best possible results. Our peptide affinity chromatography procedure is a proven methodology for isolating and extracting the necessary components of an antiserum, ensuring the high purity and potency of the final product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is recommended to store it at a temperature of -20 °C for a duration of up to one year. It is important to avoid exposing the product to repeated freeze and thaw cycles, as this may compromise its quality and efficacy. Taking these precautions will help to preserve the integrity of the product and ensure that it remains effective for its intended use.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
Celluar localization	Nucleus;
UniPort	Q96A47