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Rabbit Anti-MYL2 Polyclonal Antibody#abs137388

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Description

Catalog-specification	Delivery time	USD price
abs137388-50ug	1-2 Weeks	201.0
abs137388-100ug	1-2 Weeks	301.0

Dear valued customer,
We would like to inform you that the price provided above is for your reference purposes only. For a more detailed price, we kindly advise that you reach out to our seller Vecent.
Thank you for your understanding and we hope to hear from you soon.
Best regards,
[Your Company Name]

Overview
catalog	abs137388
Other names	The cardiac myosin light chain-2, also known as MLC-2v or myosin light chain 2 regulatory cardiac slow, is an important protein found in cardiac and ventricular muscles. Its function includes regulation of cardiac muscle contraction and relaxation. The protein is also known as CMH10, cardiac ventricular myosin light chain 2, MLC 2v, MLC2, MLRV_HUMAN, MYL 2, Myosin light polypeptide 2 regulatory cardiac slow, myosin regulatory light chain 2, myosin regulatory light chain 2 ventricular/cardiac muscle isoform, regulatory light chain of myosin, RLC of myosin, and slow cardiac myosin regulatory light chain 2. The diverse names reflect the protein's significance and the many roles it plays in the heart's function.
Source	Rabbit
Specificity	The endogenous levels of total MLC2 can be accurately detected using the MLC2 Antibody. By utilizing this antibody, researchers are able to measure the presence and quantity of MLC2 in biological samples. This detection method is reliable and enables the study of MLC2 dynamics and regulation.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Sheep;Dog;Horse
Antigen	MYL2
Application	，： ELISA(peptide) 1:20000-1:40000，WB 1:1000-3000, 1:100-1:500。，ELISA（）1:20000-1:40000，WB1:1000-30001:100-1:500。
Immunogen	A synthesized peptide derived from human MLC2.
MW	19 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar description can be derived by reordering the original content, while ensuring that the information remains intact.
Clonality	Polyclonal Antibody
Stability & Storage	For preservation, it is recommended to keep the product at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to frequent freezing and thawing cycles, as this can compromise its integrity and effectiveness.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).
Posttranslational modification	N-terminus is methylated by METTL11A/NTM1.Phosphorylated by MYLK3 and MYLK2; promotes cardiac muscle contraction and function (By similarity). Dephosphorylated by PPP1CB complexed to PPP1R12B (By similarity). The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation); regulates cardiac torsion and workload distribution (By similarity).
Celluar localization	Cytoskeleton;Cytosol;
UniPort	P10916