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Rabbit Anti-IHH Polyclonal Antibody#abs137165

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Description

Catalog-specification	Delivery time	USD price
abs137165-100ug	1-2 Weeks	301.0
abs137165-50ug	1-2 Weeks	201.0

Overview
catalog	abs137165
Other names	Indian hedgehog, also known as BDA1, HHG-2, HHG2, IHH, IHH_HUMAN, is a protein that plays a critical role in embryonic development. This homolog of the hedgehog signaling pathway is involved in the formation of limbs and the development of the skeleton. Both the C- and N-product of the Indian hedgehog protein are important for proper development. Understanding the role of this protein can lead to the development of new treatments for skeletal disorders and other related conditions.
Source	Rabbit
Specificity	The endogenous levels of total IHH can be detected using the IHH Antibody. The content generated in a highly similar manner to the original text information can be rearranged as follows.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Xenopus;Chicken;Rabbit;
Antigen	IHH
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IHH.
MW	45 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography with SulfoLink™ Coupling Resin was employed for the purification of the antiserum. The resulting product was highly purified and free of impurities.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to keep the items in a freezer at a temperature of -20 °C for up to a year to ensure their quality. It is important to avoid subjecting the items to repeated cycles of freezing and thawing, as this can impact their stability and effectiveness.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at -20 °C and it's stable for 12 months from the point of receipt.
Target
Background	Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).
Tissue specificity	Expressed in embryonic lung, and in adult kidney and liver.
Posttranslational modification	The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity (By similarity).Cholesterylation is required for N-product targeting to lipid rafts and multimerization.Palmitoylated. N-palmitoylation is required for N-product multimerization and full activity.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q14623