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Rabbit Anti-ASPP2 Polyclonal Antibody#abs132675

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Description

Catalog-specification	Delivery time	USD price
abs132675-100ug	1-2 Weeks	301.0
abs132675-50ug	1-2 Weeks	201.0

Overview
catalog	abs132675
Description	This regulatory protein exerts a central role in the regulation of apoptosis and cell growth through its interactions. It effectively enhances the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo, thereby regulating TP53. Furthermore, it hinders the ability of APPBP1 to conjugate NEDD8 to CUL1, consequently diminishing APPBP1's capacity to induce apoptosis. Additionally, it acts as a hindrance to cell cycle progression at G2/M. Interestingly, the interaction between this protein and DDX42 inhibits its apoptosis-stimulating activity.
Other names	ASPP2, also known as apoptosis-stimulating of p53 protein 2 or p53-binding protein 2, is a tumor suppressor protein that plays a crucial role in regulating cell death. It interacts with the tumor suppressor protein p53 and enhances its ability to induce apoptosis, or programmed cell death, in response to DNA damage or other cellular stress. ASPP2 is also known as BBP, or Bcl2-binding protein, due to its ability to interact with and modulate the activity of the anti-apoptotic protein Bcl2. In addition, it has been identified as the NY REN 51 antigen, a marker for renal carcinoma. ASPP2 is encoded by the PPP1R13A gene and has been found to be mutated or downregulated in various types of cancer, including breast, ovarian, and lung cancer. Its role in tumor suppression has made it a target for cancer therapy, with drugs being developed to restore its function and enhance its anti-tumor activity.
Source	Rabbit
Specificity	Endogenous levels of total ASPP2 can be detected using the ASPP2 antibody. This antibody is effective in identifying the protein in a variety of samples, highlighting its versatility for use in different research applications. By targeting ASPP2, researchers can gain insight into the role of this important protein in cellular processes. Whether studying cancer progression, apoptosis or cell growth, the ASPP2 antibody can be an invaluable tool in the laboratory.
Species Reactivity	Human;Mouse
Antigen	ASPP2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	170 kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
Tissue specificity	Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.
Celluar localization	Mitochondrion;Nucleus;
UniPort	Q13625