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Rabbit Anti-TNF18 Polyclonal Antibody#abs132862

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Description

Catalog-specification	Delivery time	USD price
abs132862-100ug	1-2 Weeks	301.0
abs132862-50ug	1-2 Weeks	201.0

Overview
catalog	abs132862
Description	This xenobiotic transporter has been identified as a key player in the brain's defense against foreign substances. Its role in removing xenobiotics from the brain and facilitating brain-to-blood efflux has been found to be significant. Furthermore, it has been observed that this transporter plays a crucial part in conferring multidrug resistance in various cancer cell lines. When this transporter is overexpressed, the cells become resistant to drugs like mitoxantrone, daunorubicin, and doxorubicin. Moreover, the intracellular accumulation of daunorubicin is reduced, and there is an ATP-dependent increase in the efflux of rhodamine 123.
Other names	Tumor necrosis factor ligand 2A, also known as Activation-inducible TNF-related ligand or AITRL, is a member of the tumor necrosis factor ligand superfamily. It is also referred to as Glucocorticoid induced TNF-related ligand or GITRL. This protein is encoded by the TNFSF18 gene and is involved in immune regulation. AITRL/GITRL can be induced by activation and plays a crucial role in immune responses. It is known to bind to its receptor GITR, also known as glucocorticoid-induced TNFR-related protein. This ligand-receptor interaction is important for immune cell activation, proliferation, and cytokine production. In addition to its role in immune regulation, AITRL/GITRL has been associated with various diseases. It has been implicated in autoimmune disorders, inflammation, and cancer. Studies have shown that targeting this ligand-receptor system may have therapeutic potential in modulating immune responses and treating these diseases. In summary, AITRL/GITRL is an activation-inducible protein that belongs to the tumor necrosis factor ligand superfamily. It plays a critical role in immune regulation and has implications in various diseases. Further research is needed to fully understand its mechanisms and explore its therapeutic potential.
Source	Rabbit
Specificity	Endogenous levels of total TNF18 can be accurately detected using the TNF18 antibody. To create a closely resembling content, rearrange the sentence, keeping the information consistent.
Species Reactivity	Human
Antigen	TNF18
Application	The recommended dilution for western blot is between 1:500-1:2000, for immunohistochemistry it is between 1:50-1:200, and for ELISA using peptide antigens it is between 1:20000-1:40000. It is important to carefully optimize the dilution for each application to ensure optimal results. Diluting the primary antibody too much may result in weak or undetectable signal, while diluting it too little may lead to non-specific background staining. Therefore, it is recommended to perform a small titration experiment to determine the optimal dilution for each experiment.
Immunogen	A synthesized peptide.
MW	72 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. A highly similar content can be created by rephrasing the original sentence as follows: The SulfoLink™ Coupling Resin was utilized in purifying the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Tissue specificity	Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q9UNG2