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Rabbit Anti-KIR2DL1 Polyclonal Antibody#abs136080

Please note that the price mentioned is for your reference only. To get the accurate details, kindly contact our seller Vecent. Western blot analysis of extracts of HepG2cell lines, using KIR2DL1antibody. This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs136080-100ug	1-2 Weeks	301.0
abs136080-50ug	1-2 Weeks	201.0

Please note that the price mentioned is for your reference only. To get the accurate details, kindly contact our seller Vecent.

Overview
catalog	abs136080
Description	Killer cell immunoglobulin-like receptors (KIRs) are expressed by natural killer cells and subsets of T cells. These receptors are transmembrane glycoproteins. They are located on chromosome 19q13.4 within the leukocyte receptor complex (LRC), which is approximately 1 Mb in size. The KIR genes are polymorphic and highly homologous, meaning they have multiple variations and are very similar to each other. While the specific gene content of the KIR gene cluster can vary among different haplotypes, certain framework genes are present in all haplotypes, including KIR3DL3, KIR3DP1, KIR3DL4, and KIR3DL2. The KIR proteins can be classified based on the number of extracellular immunoglobulin domains they possess, which can be either 2D or 3D. Additionally, they can be grouped based on whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with a long cytoplasmic domain transmit inhibitory signals when they bind to their ligands, using an immune tyrosine-based inhibitory motif (ITIM). On the other hand, KIR proteins with a short cytoplasmic domain do not have the ITIM motif but instead associate with the TYRO protein tyrosine kinase binding protein to transmit activating signals. Several KIR proteins have been identified to have specific ligands within the subset of HLA class I molecules. This suggests that KIR proteins play an important role in regulating the immune response. The interaction between KIRs and their ligands is believed to be crucial in determining the activation or inhibition of natural killer cells and T cells, thus modulating immune responses. The highly diverse and polymorphic nature of KIR genes contributes to the complexity and variability of immune regulation.
Other names	The CD158 antigen-like family member A, also known as CD158a or Killer cell immunoglobulin-like receptor 2DL1, is a natural killer cell receptor that belongs to the MHC class I NK cell receptor family. It is also commonly referred to as p58 NK receptor or p58.1 MHC class-I-specific NK receptor, and has several other aliases such as KI2L1_HUMAN, KIR-K64, KIR221, NKAT 1, NKAT, NKAT-1, p58 natural killer cell receptor clones CL-42/47.11, and p58.1. This receptor is characterized by having two long cytoplasmic domains and is important for regulating the activation of natural killer cells. It recognizes MHC class I molecules and helps to distinguish healthy cells from infected or cancerous cells for targeting by the immune system. The CD158 antigen-like family member A is an essential component of the immune surveillance system and plays a critical role in protecting the body against a variety of pathogenic invaders. Understanding the functions and mechanisms of this receptor can provide valuable insights into the development of targeted therapies for various diseases.
Source	Rabbit
Specificity	The KIR2DL1 Antibody has the ability to identify the complete amount of KIR2DL1 present within a cell or system without any alterations.
Species Reactivity	Human;Mouse
Antigen	KIR2DL1
Application	To obtain accurate and reliable results, it is recommended to use WB at a dilution range of 1:500-1:2000, IHC at a dilution range of 1:50-1:200, and ELISA (peptide) at a dilution range of 1:20000-1:40000. These dilutions have been determined based on previous experiments and are known to provide optimal results. It is important to follow the recommended dilution ranges to avoid false positives or negatives in your experiments. By using the correct dilutions, you can ensure that your results are reliable and accurate, which is essential for successful scientific research.
Immunogen	A synthesized peptide derived from human KIR2DL1.
MW	39kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Celluar localization	Plasma Membrane;
UniPort	P43626