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Rabbit Anti-KIR2DL3 Polyclonal Antibody#abs136081

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Description

Catalog-specification	Delivery time	USD price
abs136081-100ug	1-2 Weeks	301.0
abs136081-50ug	1-2 Weeks	201.0

Overview
catalog	abs136081
Description	Killer cell immunoglobulin-like receptors (KIRs) are expressed on natural killer cells and subsets of T cells as transmembrane glycoproteins. These KIR genes are highly homologous and polymorphic in nature and are situated in a cluster on chromosome 19q13.4 within the leukocyte receptor complex (LRC). Although the gene content of the KIR gene cluster varies among haplotypes, several framework genes are commonly found in all haplotypes, such as KIR3DL3, KIR3DP1, KIR3DL4, and KIR3DL2. The KIR proteins differ in their extracellular immunoglobulin domains (2D or 3D) and by the length of their cytoplasmic domain (long or short). KIR proteins containing the long cytoplasmic domain transmit inhibitory signals through an immune tyrosine-based inhibitory motif (ITIM) upon ligand binding, while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead interact with the TYRO protein tyrosine kinase binding protein to incite activating signals. KIR proteins are known to regulate the immune response by binding to subsets of HLA class I molecules, making them critical in modulating immunity. [Reference: RefSeq, Jul 2008]
Other names	CD158 antigen-like family member B2, also known as KIR2DL3, is a natural killer cell-associated transcript 2 that functions as a killer cell immunoglobulin-like receptor. It is expressed on the surface of natural killer cells and recognizes MHC class I molecules. It is a member of the CD158 antigen-like family and is known by various aliases, including p58 NK receptor CL-6, KIR-K7b, and GL183. The KIR2DL3 receptor has a long cytoplasmic tail and is involved in the inhibition of killing activity by natural killer cells. It is encoded by the KIR2DL3 gene and is closely related to KIR2DS5. Overall, CD158 antigen-like family member B2 is a crucial protein involved in the regulation of natural killer cell activity and plays an essential role in immune surveillance.
Source	Rabbit
Specificity	Total KIR2DL3 levels are detected by the KIR2DL3 Antibody, which can effectively bind to endogenous KIR2DL3 protein.
Species Reactivity	Human;Mouse
Antigen	KIR2DL3
Application	WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human KIR2DL3.
MW	38kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
Celluar localization	Plasma Membrane;
UniPort	P43628