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Rabbit Anti-HMG17 Polyclonal Antibody#abs133372

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Description

Catalog-specification	Delivery time	USD price
abs133372-100ug	1-2 Weeks	301.0
abs133372-50ug	1-2 Weeks	201.0

Overview
catalog	abs133372
Other names	High mobility group protein 17, also known as nonhistone chromosomal protein HMG 17 or HMG17, is a protein that binds to nucleosomes and is involved in chromatin remodeling. It contains a high mobility group nucleosome-binding domain and is a non-histone chromosomal protein. The human gene that codes for this protein is called HMGN2, which stands for high mobility group nucleosomal binding domain 2. Other names for this gene include high mobility group nucleosome-binding domain-containing protein 2 and MGC5629. HMG17 is important for regulating gene expression and has been shown to play a role in a variety of cellular processes, including DNA repair, replication, and transcription. It is also involved in the development and progression of cancer. Overall, the high mobility group protein 17 is a key player in the complex and dynamic world of chromatin biology. Its functions are numerous and varied, making it an essential component of many cellular processes.
Source	Rabbit
Specificity	The total levels of endogenous HMG17 can be detected using the HMG17 Antibody. The antibody is designed to specifically recognize and bind to HMG17 protein, allowing for the accurate measurement of its presence.
Species Reactivity	Human;Mouse;Rat
Antigen	HMG17
Application	The recommended dilutions for this protein are WB 1:500-1:2000, IHC 1:50~1:200, IF/ICC 1:100-1:500, and ELISA(peptide) 1:20000-1:40000. It is crucial to follow the proper dilution guidelines to achieve accurate and reliable results. Proper dilution ensures that the target protein is appropriately labeled and detected with minimal background noise. It is recommended to perform an optimization experiment to determine the ideal dilution for each assay and sample type. Overall, these dilution guidelines provide a solid starting point for obtaining high-quality results with this protein.
Immunogen	A synthesized peptide.
MW	9 KD
Properties
Concentration	1mg/ml
purification	Through the use of SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. This highly effective process ensures that any impurities are removed from the antiserum, resulting in a final product that is of the highest quality.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is advised to avoid subjecting the product to frequent freeze/thaw cycles, as this could lead to its deterioration over time. Ensure that appropriate storage measures are taken to preserve the integrity of the product and avoid any potential damage that could compromise its effectiveness.
Storage buffer	This solution contains Rabbit IgG in a buffer of phosphate saline with a pH of 7.4. It also contains 150mM NaCl, 0.02% sodium azide and 50% glycerol. To maintain its stability, it should be stored at a temperature of -20°C. This product has a shelf life of 12 months from the date of purchase.
Target
Background	Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).
Posttranslational modification	Phosphorylation favors cytoplasmic localization.
Celluar localization	Extracellular region or secreted;Nucleus;
UniPort	P05204

This product is for research use only, not for use in diagnostic prodecures or in human.

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