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Rabbit Anti-AURKC Polyclonal Antibody#abs137147

Please note that the price provided is only for your reference. For detailed pricing information, we recommend getting in touch with our seller, Vecent. Western blot analysis AURKC using K562 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in...

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Description

Catalog-specification	Delivery time	USD price
abs137147-100ug	1-2 Weeks	301.0
abs137147-50ug	1-2 Weeks	201.0

Please note that the price provided is only for your reference. For detailed pricing information, we recommend getting in touch with our seller, Vecent.

Overview
catalog	abs137147
Other names	AURKC, also known as AIE2, AIE1, AIK3, ARK3, or Aurora C, is a serine/threonine protein kinase that plays a crucial role in cell cycle regulation and mitotic spindle formation. It belongs to the Aurora/Ipl1-related kinase family and is closely related to Aurora kinase A and B. AURKC is expressed in various tissues, including the testis, ovary, and placenta, and its overexpression has been associated with several types of cancer. AURKC has also been implicated in germ cell development and meiosis, making it a potential target for fertility treatments. As a promising therapeutic target, AURKC is currently being investigated for its anti-tumor activity and its role in other disease states.
Source	Rabbit
Specificity	The AURKC Antibody is designed to identify the overall levels of endogenous AURKC protein. By rearranging the original content, this statement can be restated as: Detection of total AURKC protein at its natural levels can be accomplished using the AURKC Antibody.
Species Reactivity	Human
Antigen	AURKC
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human AURKC.
MW	36 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography process for purifying the antiserum. To ensure purification, the original content describes that peptide affinity chromatography was employed, which involved the use of SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality, store it at -20 °C for one year, taking care to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	The rabbit IgG is suspended in a solution of phosphate buffered saline, pH 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For storage, it should be kept at -20 °C, and will remain stable for up to 12 months from the date of receipt. This antibody is crucial for any study involving rabbit immunoglobulin, and the high quality of this preparation ensures reliable results. Simply thaw the solution and treat it as directed for your specific experimental protocol. Don't let your rabbit IgG research suffer from unreliable reagents - choose this superior preparation for your study.
Target
Background	Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Tissue specificity	Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
Celluar localization	Cytoskeleton;Nucleus;
UniPort	Q9UQB9