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Rabbit Anti-FMO3 Polyclonal Antibody#abs136203

Please be advised that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis of extracts of mouse livercell lines, using FMO3 antibody. This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs136203-100ug	1-2 Weeks	301.0
abs136203-50ug	1-2 Weeks	201.0

Please be advised that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs136203
Description	Flavin-containing monooxygenases (FMOs) are critical enzymes involved in the metabolism of drugs, pesticides, and other foreign compounds in the body. These enzymes require NADPH to catalyze the oxidation of xenobiotics containing nitrogen, sulfur, or phosphorus. The human FMO gene family comprises five genes and various pseudogenes. Interestingly, different members of this gene family have unique tissue-specific and developmental expression patterns. In particular, FMO3 is the primary FMO expressed in adult liver and can differ up to 20-fold in its expression levels between individuals. The inter-individual variability in FMO3 expression can significantly impact the rate at which xenobiotics are metabolized, making it of great interest to the pharmaceutical industry. FMO3 is a transmembrane protein that localizes to the endoplasmic reticulum in several tissues, and alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in the FMO3 gene cause a genetic disorder called trimethylaminuria (TMAu), which is characterized by the accumulation and excretion of unmetabolized trimethylamine, leading to a distinct body smell. However, healthy individuals typically convert trimethylamine to the non-odorous trimethylamine N-oxide. Overall, FMOs play a vital role in drug metabolism and have significant physiological effects that require further exploration.
Other names	This is a list of various names and labels applied to a specific enzyme called Dimethylaniline monooxygenase [N-oxide-forming] 3. The enzyme is also referred to as Dimethylaniline monooxygenase 3, Dimethylaniline oxidase 3, Flavin containing monooxygenase 3, FMO 3, FMO form 2, FMO II, FMO3, FMO3_HUMAN, FMOII, Hepatic flavin containing monooxygenase 3, Hepatic flavin-containing monooxygenase 3, MGC34400, TMAU, and Trimethylamine monooxygenase. Despite the different names, they all refer to the same enzyme and its catalytic function.
Source	Rabbit
Specificity	The total FMO3 levels present within the body can be detected using the FMO3 Antibody. This antibody is capable of identifying endogenous levels of FMO3 and thus, can be used for research and diagnostic purposes. To create similar content, one can rearrange the language of the original text to convey the same message.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;Rabbit;Pig;
Antigen	FMO3
Application	WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human FMO3.
MW	60kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds (PubMed:9224773).
Tissue specificity	Liver.
Celluar localization	Endoplasmic reticulum;
UniPort	P31513