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Rabbit Anti-FKBP1A Polyclonal Antibody#abs136119

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Description

Catalog-specification	Delivery time	USD price
abs136119-100ug	1-2 Weeks	301.0
abs136119-50ug	1-2 Weeks	201.0

Overview
catalog	abs136119
Description	This gene encodes a protein that belongs to the immunophilin protein family. These proteins are involved in immunoregulation, as well as important cellular processes like protein folding and trafficking. The encoded protein specifically functions as a cis-trans prolyl isomerase and has affinity for immunosuppressants such as FK506 and rapamycin. It interacts with various intracellular signal transduction proteins, including the type I TGF-beta receptor. Additionally, it interacts with multiple calcium release channels within cells and plays a role in coordinating the formation of a complex involving the tetrameric skeletal muscle ryanodine receptor. Interestingly, in mice, the deletion of a similar gene leads to a congenital heart disorder called noncompaction of left ventricular myocardium. Numerous alternatively spliced variants of this gene have been identified, all encoding the same protein. In the human genome, there are five related pseudogenes, with at least one being transcribed. This information has been derived from RefSeq, a comprehensive database. Please note that the generated content is rearranged and rephrased to preserve the original information.
Other names	FK506-binding protein 1A, also known as FKBP12 or FKB1A_HUMAN, is a protein found in humans that binds to the immunosuppressant drug FK506. It is primarily involved in protein folding and catalyzes the cis-trans isomerization of proline residues in proteins. FKBP1A is composed of 12 kDa and is also known as Calstabin 1, FK506 binding protein T cell 12 kDa, or Protein kinase C inhibitor 2. The function of FKBP1A is critical in immune regulation and cell signaling. It plays an essential role in the formation and activation of calcineurin, a phosphatase that is involved in the transcription of pro-inflammatory cytokines. Moreover, FKBP1A is an essential modulator of the Ryanodine receptor, a calcium channel in the sarcoplasmic reticulum of muscle cells. Dysfunction of this protein has been associated with a variety of disorders, including immunodeficiencies, cardiovascular diseases, and neurodegenerative diseases. In summary, FKBP1A is a multifunctional protein that plays a crucial role in modulating several cellular processes. Its diverse functions underscore its importance in maintaining cellular homeostasis and health.
Source	Rabbit
Specificity	The total FKBP1A can be detected by using the FKBP1A Antibody which is capable of recognizing the endogenous levels. Simply put, the antibody is designed to detect the entire FKBP1A protein that is present in the sample being tested.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Bovine;Rabbit
Antigen	FKBP1A
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: WB dilutions range from 1:500 to 1:2000, IHC dilutions range from 1:50 to 1:200, and ELISA (peptide) dilutions range from 1:20000 to 1:40000. It is important to note that these dilution ranges provide a guideline for the appropriate dilutions for each assay. Dilution factors may vary depending on the specific experimental conditions and the target protein. Proper optimization of dilutions is crucial for obtaining reliable and accurate results in WB, IHC, and ELISA experiments using the specified techniques.
Immunogen	A synthesized peptide derived from human FKBP1A.
MW	12kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Celluar localization	Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Plasma Membrane;
UniPort	P62942