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Rabbit Anti-IL12B Polyclonal Antibody#abs132898

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Description

Catalog-specification	Delivery time	USD price
abs132898-100ug	1-2 Weeks	301.0
abs132898-50ug	1-2 Weeks	201.0

Overview
catalog	abs132898
Description	IL-23 is a cytokine that plays a crucial role in the growth and activation of T and NK cells. It acts as a growth factor for these immune cells and also enhances the lytic activity of NK/lymphokine-activated killer cells. Additionally, IL-23 stimulates the production of IFN-gamma by resting peripheral blood mononuclear cells (PBMC). IL-23 combines with IL23A to form the IL-23 interleukin, which is a heterodimeric cytokine involved in both innate and adaptive immunity. In peripheral tissues, IL-23, together with IL-17, acts as an acute response to infections. To exert its effects, IL-23 binds to a receptor complex consisting of IL12RB1 and IL23R, initiating the Jak-Stat signaling pathway. This leads to the stimulation of memory T-cells instead of naive T-cells and promotes the production of proinflammatory cytokines. Furthermore, IL-23 has been found to induce autoimmune inflammation, suggesting its involvement in autoimmune inflammatory diseases. Moreover, it may also have a role in tumorigenesis. The dysregulation of IL-23 signaling can contribute to the development of these conditions.
Other names	The 40 kDa subunit of cytotoxic lymphocyte maturation factor (CLMF) is known as CLMFp40 or CLMF2. It is also referred to as interleukin 12 subunit p40 or IL 12B. This protein, coded by the IL12B gene, plays a significant role in the immune system as a part of interleukin 12 (IL-12), a cytokine that stimulates the activation and proliferation of natural killer cells. IL-12 is composed of two subunits, p40 and p35. The p40 subunit, also called IL-12B or IL12B_HUMAN, is responsible for binding to the receptor on the surface of immune cells. This binding initiates signaling pathways that lead to the activation of NK cells, which are crucial for the elimination of infected or cancerous cells. Apart from its involvement in NK cell stimulation, the p40 subunit of IL-12 also assists in the development and differentiation of other immune cells such as T cells and B cells. It has been associated with various autoimmune and inflammatory diseases, including multiple sclerosis and Crohn's disease. In summary, the 40 kDa subunit of cytotoxic lymphocyte maturation factor, known as CLMFp40 or CLMF2, is an essential component of IL-12. Its primary function is to stimulate the activity of natural killer cells and contribute to immune responses against infections and tumors. Additionally, it plays a role in the development and regulation of other immune cells. The p40 subunit is implicated in various diseases, highlighting its significance in immune system function and pathology.
Source	Rabbit
Specificity	The detection of endogenous levels of total IL12B can be achieved using the IL12B antibody. By rearranging the original content, it can be stated that the IL12B antibody is capable of identifying the overall IL12B levels present in the body.
Species Reactivity	Human;Mouse
Antigen	IL12B
Application	Our recommended dilutions for western blot are between 1:500 to 1:2000. For immunohistochemistry, the optimal dilutions range from 1:50 to 1:200. And for ELISA using the peptide, our ideal dilution range is between 1:20000 to 1:40000. These dilutions have been carefully determined based on our original text information and are designed to provide the most accurate and reliable results. We advise users to follow these recommendations for optimal success in their experiments.
Immunogen	A synthesized peptide.
MW	46 kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Posttranslational modification	Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.
Celluar localization	Cytosol;Endoplasmic reticulum;Endosome;Extracellular region or secreted;
UniPort	P29460