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Rabbit Anti-IL11 Polyclonal Antibody#abs132897

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Description

Catalog-specification	Delivery time	USD price
abs132897-100ug	1-2 Weeks	301.0
abs132897-50ug	1-2 Weeks	201.0

Overview
catalog	abs132897
Description	This cellular mechanism directly triggers the growth and multiplication of hematopoietic stem cells as well as the development of megakaryocyte progenitor cells. As a consequence, it facilitates the maturation of megakaryocytes, ultimately leading to a significant boost in platelet production.
Other names	IL-11, also known as Adipogenesis Inhibitory Factor or AGIF, is a cytokine that plays an important role in a variety of physiological processes, including bone metabolism, hematopoiesis, and neuronal survival. This protein is often used therapeutically, with the drug Oprelvekin derived from IL-11, to treat conditions such as thrombocytopenia and osteoporosis. IL-11 interacts with specific receptors on target cells to initiate signaling pathways that ultimately lead to changes in gene expression and cellular responses. Overall, IL-11 is a versatile and effective signaling molecule with a wide range of applications in both clinical and research settings.
Source	Rabbit
Specificity	The IL11 antibody is capable of identifying total IL11 present naturally within the body. This means that the antibody specifically detects the total amount of IL11 that is present, without reacting to any other substances.
Species Reactivity	Human;Mouse;Rat
Antigen	IL11
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	27 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. To ensure the highest level of purity, this method effectively removed any unwanted impurities from the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is advisable to avoid subjecting the product to repeated cycles of freezing and thawing. This will help to ensure that the product remains usable and effective for its intended purpose.
Storage buffer	In a solution of phosphate buffered saline with a pH of 7.4 and 150mM of NaCl, you'll find Rabbit IgG. This solution also contains 0.02% sodium azide and 50% glycerol to help preserve the contents.
Target
Background	Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
Celluar localization	Extracellular region or secreted;
UniPort	P20809