Rabbit Anti-Cox1 Polyclonal Antibody #abs130075

abs130075-50ug

1-2 Weeks

201

abs130075-100ug

1-2 Weeks

301

Description

The cyclooxygenase-1 protein is a crucial player in the regulation and promotion of cell growth within both normal and cancerous cells. This protein belongs to the prostaglandin G/H synthase family and exists as a homodimer. Interestingly, there are two distinct isoforms of this protein that are created via alternative splicing. Essentially, this means that the same protein can have slightly different forms which may impact its function in specific cells or conditions.

Other names

1. COX-1, also known as prostaglandin-endoperoxide synthase 1 or cyclooxygenase 1, is an important enzyme involved in the synthesis of prostaglandins and thromboxane A2. It is encoded by the PTGS1 gene.
2. COX-3, on the other hand, is a variant of the cyclooxygenase enzyme that was initially thought to exist in humans but later found to be primarily expressed in the brains of dogs. It is encoded by the PTGS2 gene.
3. Cyclooxygenase 1 (COX-1) and cyclooxygenase 3 (COX-3) play different roles in the body. While COX-1 is constitutively expressed in various tissues and is involved in maintaining normal physiological functions, COX-3 is more specific to the central nervous system and is associated with pain perception and inflammation.
4. COX1 and Cox3 refer to the same enzymes, cyclooxygenase 1 and cyclooxygenase 3, respectively.
5. Another name for COX-1 is prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase).
6. The EC 1.14.99.1 is the Enzyme Commission number assigned to COX-1, indicating its classification as an oxidoreductase catalyzing the formation of prostaglandins.
7. Partial COX1 proteins are also included in the category of COX-1 enzymes.
8. Other names for COX-1 include PGH synthase 1, PGH1_HUMAN, PGHS-1, PGHS1, PHS 1, PHS1, and Prostaglandin H2 synthase 1.
9. COX-1 is responsible for the synthesis of prostaglandins and thromboxane A2 from arachidonic acid, playing a crucial role in various physiological processes such as inflammation, pain sensation, and platelet aggregation.
10. PTGHS and PTGS1 are alternative gene names for COX-1, representing prostaglandin-endoperoxide synthase 1.
Please note that the rearranged content may have a different sequence but still focuses on providing information about COX-1, COX-3, and their various names and functions.

Source

Rabbit

Specificity

The detection of endogenous levels of total Cox1 can be accomplished using the Cox1 antibody. By targeting this specific protein, the antibody can provide accurate and reliable results.

Species Reactivity

Human;Rat

Application

The suggested dilution ratios for using this antibody in various applications are as follows: 1:500~1:3000 for Western Blot (WB), 1:50~1:200 for Immunohistochemistry (IHC), 1:100-1:500 for Immunofluorescence/Immunocytochemistry (IF/ICC), and 1:20000-1:40000 for ELISA (peptide). These dilution ratios are optimized for ensuring optimal performance of the antibody and should be used as a reference for your experimental needs.

Immunogen

A synthesized peptide derived from human Cox1.

Properties

Concentration

1mg/ml

Purification

Peptide affinity chromatography using SulfoLink™ Coupling Resin was utilized to purify the antiserum. To generate highly similar content by rearranging the given information, it was necessary to employ SulfoLink™ Coupling Resin for the purification of the antiserum through peptide affinity chromatography.

Clonality

Polyclonal Antibody

Stability & Storage

One year storage is recommended at -20 °C, taking care to avoid repeated freeze/thaw cycles. It is important to store the product within this temperature range to ensure its integrity.

Storage buffer

The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of this antibody is guaranteed for 12 months from the date of receipt.

Target

Background

The conversion of arachidonate to prostaglandin H2 (PGH2) is a crucial step in the synthesis of prostanoids. This process is particularly involved in the continuous production of prostanoids in the stomach and platelets. In the gastric epithelial cells, it acts as a key player in the creation of prostaglandins like prostaglandin E2 (PGE2), which plays a significant role in safeguarding the cell lining. Platelets rely on this conversion to generate thromboxane A2 (TXA2), a compound that stimulates platelet activation, aggregation, vasoconstriction, and the expansion of smooth muscle cells in blood vessels.

Celluar localization

Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;Nucleus;

UniPort

P23219