Rabbit Anti-Annexin A6 Polyclonal Antibody #abs130053

abs130053-50ug

1-2 Weeks

201

abs130053-100ug

1-2 Weeks

301

Description

ANXA6 is a protein that binds to calcium and phospholipids, and it may interact with CD21. It has the potential to control the release of calcium from cellular reservoirs. When stimulated by growth factors, ANXA6 can undergo phosphorylation. Annexins constitute a group of proteins that share a similar structure and have the ability to bind to phospholipids in a calcium-dependent manner. In mammals, there are at least ten different types of annexins. It is interesting to note that even though annexins, such as A1, A2, and A5, lack signal peptides, they are believed to be secreted in a regulated manner as part of normal physiological processes.

Other names

Annexin A6, also known as Annexin VI or calelectrin, is a calcium-binding protein in humans. It is encoded by the ANXA6 gene and is a member of the annexin family of proteins. Annexin A6 has various aliases such as lipocortin VI, calphobindin-II, chromobindin-20, and protein III.
Annexin A6 binds to cell membranes in a calcium-dependent manner and is involved in various cellular processes such as exocytosis, endocytosis, and membrane trafficking. It also plays a role in regulating cytoskeletal organization and cell signaling.
The protein has a molecular weight of 67 kDa and exists in two isoforms, one of which is p68. It is widely expressed in various tissues including the brain, heart, and lungs. Annexin A6 has been implicated in various diseases such as cancer, neurodegeneration, and cardiovascular diseases.
In conclusion, Annexin A6 is a calcium-binding protein that plays an important role in various cellular processes and has been implicated in various diseases. It is also known by various aliases such as lipocortin VI, calphobindin-II, and chromobindin-20.

Source

Rabbit

Specificity

The total Annexin A6 levels in cells can be effectively detected using the Annexin A6 antibody, which specifically recognizes the endogenous expression of Annexin A6. This antibody provides a reliable tool to analyze and study the presence and abundance of Annexin A6 in biological samples.

Species Reactivity

Human;Mouse

Application

For Western blotting, the recommended dilution range is between 1:500 to 1:3000. When it comes to immunohistochemistry, dilutions ranging from 1:50 to 1:200 are advised. For immunofluorescence and immunocytochemistry, it is recommended to use a dilution range of 1:100 to 1:500. Finally, for ELISA using peptides, the appropriate dilution range is between 1:20000 to 1:40000. It is essential to ensure that the correct dilution is used for each application to obtain optimal results.

Immunogen

Annexin A6 is the source of a synthesized peptide that has been developed. This peptide is designed to closely resemble the original human Annexin A6 and provide similar properties and functions. Researchers have carefully rearranged the amino acid sequence of Annexin A6 to create this synthetic peptide. By deriving the peptide from Annexin A6, scientists aim to harness its potential therapeutic benefits and explore its role in various biological processes. The synthesized peptide holds promise for further studies and potential applications in medicine and biotechnology.

Properties

Concentration

1mg/ml

Purification

We utilized SulfoLink™ Coupling Resin for peptide affinity chromatography in order to purify the antiserum. Please rearrange the given information to create similar content while maintaining the essence of the original text.

Clonality

Polyclonal Antibody

Stability & Storage

To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for one year. It is important to avoid subjecting it to repeated freeze/thaw cycles.

Storage buffer

The storage and stability details for Rabbit IgG in phosphate buffered saline, pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol are as follows: Store the product at a temperature of -20 °C. It is stable for a duration of 12 months starting from the date of receipt.

Target

Background

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

Tissue specificity

By Epstein-Barr virus (EBV).

Posttranslational modification

Phosphorylated in response to growth factor stimulation.

Celluar localization

Endosome;Extracellular region or secreted;Lysosome;Mitochondrion;

UniPort

P08133