Rabbit Anti-CD34 Polyclonal Antibody#abs131132

abs131132-50ug

1-2 Weeks

201

abs131132-100ug

1-2 Weeks

301

Description

An adhesion molecule may play a critical role in early hematopoiesis by facilitating the binding of stem cells to the bone marrow extracellular matrix or to stromal cells directly. This molecule could act as a framework for the binding of lineage-specific glycans, enabling stem cells to attach to lectins expressed by stromal cells or other bone marrow components. Furthermore, it could offer carbohydrate ligands to selectins, allowing for interaction between cells.

Other names

The CD34 molecule, also known as the CD34 antigen or hematopoietic progenitor cell antigen CD34, is a glycoprotein that plays a crucial role in hematopoiesis. It is expressed on the surface of hematopoietic stem cells and endothelial precursor cells, and is involved in cell adhesion and signaling.
CD34 is also referred to as cluster designation 34, HPCA1, mucosialin, OTTHUMP00000034733, and OTTHUMP00000034734. Studies have shown that CD34 can serve as a marker for identifying hematopoietic stem cells in bone marrow and peripheral blood stem cell transplantation.
This highly important molecule offers tremendous potential in cell-based therapies, drug development, and disease diagnosis and management. Its unique ability to regulate cellular function makes it an ideal target for further research and development.
In summary, CD34 is a critical glycoprotein that plays a significant role in hematopoiesis and stem cell biology. Its potential applications in various areas of medicine make it a promising target for further investigation and development.

Source

Rabbit

Specificity

The total CD34 protein at its natural level can be identified by the antibody. To create similar content using the original text information, one could say: The antibody is capable of recognizing the entirety of the CD34 protein that exists within a cell or organism, without any external influence.

Application

：ELISA(peptide)1:20000-1:40000，WB1:500-1:2000。，，ChapGPT。

Rephrased: A peptide sequence containing the amino acids Q-H-V-V-A, located around position 377 to 381 in the human CD34 protein, is requested to be generated. The generated sequence should be highly similar to the original content, while also ensuring that it is based on the same information. Please refrain from using ChapGPT to generate the content and instead use a language model to produce a completely different type of text.

Properties

1mg/ml

Purification

We employed SulfoLink™ Coupling Resin for peptide affinity chromatography to purify the antiserum. Please rearrange the given information and generate highly similar content, ensuring that it is based on the original text.

Clonality

Polyclonal Antibody

Please store at a temperature of -20 °C for a duration of one year, while ensuring that there are no repeated freeze/thaw cycles.

Storage buffer

Store the rabbit IgG in phosphate buffered saline at a pH of 7.4 with a concentration of 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C. The stability of the IgG is guaranteed for a period of 12 months from the date of receipt.

Target

Background

One potential adhesion molecule involved in early hematopoiesis is responsible for facilitating the attachment of stem cells to the extracellular matrix in the bone marrow or directly to stromal cells. It may serve as a structural support for the binding of lineage-specific glycans, enabling stem cells to effectively bind to lectins found on stromal cells or other components within the marrow. Additionally, this molecule presents carbohydrate ligands to selectins, further enhancing the interaction between stem cells and target cells. By rearranging the provided information, a similar content is generated while maintaining the essence of the original text.

Tissue specificity

Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Celluar localization

Extracellular region or secreted;Lysosome;Plasma Membrane;

P28906