Rabbit Anti-CD271 Polyclonal Antibody #abs130295

abs130295-50ug

1-2 Weeks

201

abs130295-100ug

1-2 Weeks

301

Description

The NGFR is a low affinity receptor that can bind to NGF, BDNF, NT-3, and NT-4. It plays a dual role in neural cell survival and cell death. This receptor exists as a homodimer linked by disulfide bonds. It interacts with various proteins such as p75NTR-associated cell death executor, TRAF2, TRAF4, TRAF6, PTPN13, and RANBP9. Through its association with TRAF6, NGFR forms a bridge to SQSTM1, which in turn connects it to NTRK1. Additionally, NGFR interacts with BEX1, NGFRAP1/BEX3, KIDINS220, and NTRK1.

Other names

The CD271 antigen, also known as Gp80 LNGFR or Gp80-LNGFR, is a protein commonly referred to as the low affinity nerve growth factor receptor. It is also known as the low affinity neurotrophin receptor p75NTR. Other names include the low-affinity nerve growth factor receptor, nerve growth factor receptor, nerve growth factor receptor TNFR superfamily member 16, NGF receptor, Ngfr, p75 ICD, p75 Neurotrophin receptor, p75 NTR, p75(NTR), p75NTR, TNFR Superfamily Member 16, TNFRSF16, TNR16_HUMAN, and Tumor necrosis factor receptor superfamily member 16. This particular receptor plays a crucial role in various cellular processes and is a member of the tumor necrosis factor receptor superfamily. It is essential for the binding of nerve growth factor and other neurotrophins, allowing for their signaling and regulation. The CD271 antigen is involved in the development and maintenance of the nervous system and has implications in neurodegenerative diseases and neural injury. By rearranging and rephrasing the above information, we can provide a similar content.

Source

Rabbit

Specificity

The CD271 antibody has the ability to detect the complete levels of endogenous CD271. To produce similar content, the information from the original text has been rearranged and presented.

Species Reactivity

Human;Mouse;Rat

Predictive reaction species

Pig;Rabbit;Sheep;Dog;Bovine;Horse;

Application

Western Blot（），1:5001:3000。/（IF/ICC），1:1001:500。（ELISA），1:200001:40000。

Immunogen

A synthesized peptide derived from human CD271.

Properties

Concentration

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar content can be generated by rearranging the sentence structure and retaining the key information from the original text.

Clonality

Polyclonal Antibody

Stability & Storage

To maintain the quality of the product, it is advisable to store it at a temperature of -20 °C for up to one year. It is important to note that exposing the product to repeated freeze and thaw cycles can compromise its efficacy. Therefore, it is crucial to avoid subjecting the product to such conditions to ensure optimal performance.

Storage buffer

This solution contains Rabbit IgG in phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at -20°C and can remain stable for up to 12 months from the date of receipt. It is important to note that the content of this solution should not be generated using the ChapGPT text-generating technique. Instead, a language model should be used to ensure that the generated text is completely different from the original text.

Target

Background

The protein plays a crucial role in regulating insulin-dependent glucose uptake in adipocytes and skeletal muscle cells by controlling RAB31 activity and facilitating the translocation of GLUT4 to the cell surface in response to insulin. Additionally, it acts as a low-affinity receptor for NGF, BDNF, NT-3, and NT-4 and can promote cell survival or death of neural cells. This protein is also essential for the circadian oscillation of clock genes in the suprachiasmatic nucleus of the brain and liver and the genes involved in glucose and lipid metabolism in the liver.

Posttranslational modification

N- and O-glycosylated.O-linked glycans consist of Gal1-3GalNAc core elongated by 1 or 2 NeuNAc.Phosphorylated on serine residues.

Celluar localization

Cytosol;Endosome;Extracellular region or secreted;Nucleus;Plasma Membrane;

UniPort

P08138