Rabbit Anti-Acetyl-Histone H4 (Lys12) Polyclonal Antibody#abs130617

abs1306017-50ug

1-2 Weeks

201

abs1306017-100ug

1-2 Weeks

301

Description

Histone H3, one of the primary histone proteins found in eukaryotic cells, is essential for maintaining the structural integrity of chromatin. It serves as a vital component of nucleosomes, which are responsible for packaging and condensing DNA into chromatin. This structural arrangement effectively regulates the accessibility of DNA to various cellular processes that rely on DNA as a template. Consequently, histones play a crucial role in governing transcription, DNA repair, DNA replication, and overall chromosomal stability.

Other names

The H3 histone family is composed of various members, including H3/A, H3FA, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, and so on. These members have different names such as Histone H3/a, Histone H3/b, Histone H3/c, or Histone H3/d. Additionally, there are variations like H3.3A, H3F3, H3f3b, H3.3Q, and others that are still part of the H3 histone family.
One of the most studied members of the H3 histone family is Histone H3.1, also known as H3. This protein is essential for packaging DNA into compact structures known as nucleosomes. Other members like H3.2 and H3.3 also have similar functions. However, they have specific roles during cell division and gene regulation.
The H3 histone family has a crucial role in epigenetics and chromatin remodeling. Specific modifications to histones, such as acetylation, methylation, and phosphorylation, can alter DNA conformation and gene expression. These modifications are reversible and allow cells to adapt to changing environments and developmental cues.
In conclusion, the H3 histone family members are critical players in maintaining genomic stability and regulating gene expression. The precise function of each member is still under investigation, but it is clear that they have significant roles in epigenetic regulation and chromatin dynamics.

Source

Rabbit

Specificity

Acetyl-Histone H3 (Lys23) Antibody detects endogenous levels of total Histone H3 protein only when acetylated at lysine23.

Application

 WB: 1:500~1:1000, IF 1:200, ELISA(peptide) 1:20000-1:40000

Immunogen

Properties

Concentration

Purification

affinity purification.

Clonality

Polyclonal Antibody

Stability & Storage

Storage buffer

Store at -20°C. Stable for one year from the date of shipment. 1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.

Target

Background

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Tissue specificity

Expressed during S phase, then expression strongly decreases as cell division slows down during the process of differentiation.

Celluar localization

Extracellular region or secreted;Nucleus;

UniPort

P68431/Q71DI3/P84243