Phospho-Leptin Receptor (Tyr986) Rabbit Polyclonal Antibody#abs140048
Please note that the price provided above is only for your reference. For detailed pricing information, we advise you to get in touch with our seller Vecent. It is essential to emphasize that the content you receive will be highly similar but rearranged to ensure it meets your requirements...
Description
| Catalog-specification | Delivery time | USD price |
abs140048-100ug | 1-2 Weeks | 301.0 |
abs140048-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided above is only for your reference. For detailed pricing information, we advise you to get in touch with our seller Vecent. It is essential to emphasize that the content you receive will be highly similar but rearranged to ensure it meets your requirements properly. Therefore, we strongly recommend that you contact our seller for further assistance. Thank you for considering us.
| Overview | |
catalog | abs140048 |
| Other names | CD 295, also known as CD295, is an important antigen that plays a significant role in various biological processes. It is sometimes referred to as Db, Fa, HuB219, or LEP R. CD295, also known as LEPR or LEPRD, represents the abbreviation for Leptin receptor, a protein that is encoded by the LEPR gene. It is involved in the regulation of leptin, a hormone that plays a crucial role in the regulation of body weight and energy balance. The precursor form of the leptin receptor is known as LEPR_HUMAN, and it undergoes processing to generate the mature form of the receptor. Additionally, there is a gene related protein called OB-RGRP, which is associated with the OB receptor, often referred to as OB-R or OB receptor-like protein. Another term used to describe the leptin receptor is "obl" or Obr. These various names and terms highlight the significance and diversity of the CD295 protein and its role in physiological processes. |
| Source | Rabbit |
| Specificity | The Leptin Receptor (Phospho-Tyr986) Antibody is capable of detecting the presence of Leptin Receptor, but only when it is phosphorylated at Tyr986 and in natural amounts within the body. This antibody is highly specific and offers reliable results for researchers examining the role of Leptin Receptor in various biological processes. |
| Species Reactivity | Human |
| Antigen | Leptin Receptor |
| Application | WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | The human Leptin Receptor (Phospho-Tyr986) can be used as a basis for creating a synthesized peptide with a highly similar structure. It is important to utilize the original text information when generating this content. However, it is advised not to rely solely on the discussion generated by ChapGPT, but rather employ a language model to deliver a speech that is completely different in approach. |
| MW | 96kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The process utilized for purifying the antibody involved utilizing rabbit serum which was then subjected to affinity purification through sequential chromatography on both phospho- and non-phospho-peptide affinity columns. This ultimately resulted in obtaining a highly effective antibody capable of detecting specific target proteins. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To preserve the product's quality, it is recommended to store it at a temperature of -20 °C for up to one year. To avoid any damage, it is essential to prevent repeated cycles of freezing and thawing. |
| Storage buffer | This Rabbit IgG solution is formulated in pH 7.4 phosphate buffered saline, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. To maintain its stability, it is recommended to store at -20°C and ensure it is used within 12 months from the date of receipt. |
Target | |
Background | Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). |
| Tissue specificity | Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus, but also in skeletal muscle. Detected in fundic and antral epithelial cells of the gastric mucosa (PubMed:19159218). Isoform B and isoform A are expressed by NK cells (at protein level) (PubMed:12504075). |
| Posttranslational modification | On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Phosphorylation of Tyr-1079 has a more accessory role. |
| Celluar localization | Extracellular region or secreted;Plasma Membrane; |
| UniPort | P48357 |
Western blot analysis Leptin Receptor (Phospho-Tyr986) using 293 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
Hot Tags: phospho-leptin receptor (tyr986) rabbit polyclonal antibody#abs140048, China phospho-leptin receptor (tyr986) rabbit polyclonal antibody#abs140048 suppliers
Send Inquiry
You Might Also Like
