Phospho-EPH B1/3/4 (Tyr778/792/774) Rabbit Polyclonal Antibody#abs140051
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Description
| Catalog-specification | Delivery time | USD price |
abs140051-100ug | 1-2 Weeks | 301.0 |
abs140051-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is only for your reference. To receive the detailed pricing information, kindly get in touch with our seller Vecent. It is essential to note that the content generated using a language model will differ from the original text. Hence, please do not follow the conversation generated by ChapGPT.
| Overview | |
catalog | abs140051 |
| Other names | Eph receptors, also known as EPH receptors, are a group of tyrosine kinase receptors that play important roles in various cellular processes. One of these receptors is EPH receptor B1, which is also called EphB1 or EPHB1. Another related receptor is Eph tyrosine kinase 2, also known as EphB2 or EPHB2. These receptors are part of the EPH receptor family and are involved in cell signaling. Another member of this family is EPH-like kinase 6, also known as Eph-like kinase 6 or EPHL6. This kinase is important for neuronal development and is expressed in the brain. Moreover, it is sometimes referred to as neuronally-expressed EPH-related tyrosine kinase or NET. In addition to these receptors, there is a soluble variant of EPHB1 called soluble EPHB1 variant 1. This variant lacks the transmembrane domain and is often found in the extracellular space, where it can interact with ephrins. Moving on to another receptor, EPH receptor B3, also known as EphB3 or EPHB3, is another member of this receptor family. It is involved in various cellular processes and is particularly important for neuronal development. Its receptor name is Ephrin receptor EphB3 or Ephrin type B receptor 3. Similarly, Eph receptor B4, also called EphB4 or EPHB4, is another member. It is known for its role in angiogenesis and is also referred to as Ephrin receptor EphB4 or Ephrin type-B receptor 4. Overall, the EPH receptors are a diverse group of tyrosine kinase receptors that play crucial roles in various biological processes such as development and cell signaling. |
| Source | Rabbit |
| Specificity | The EPH B1/3/4 (Phospho-Tyr778/792/774) Antibody is capable of detecting naturally occurring levels of EPH B1/3/4, but only when these proteins are phosphorylated at Tyr778/792/774. To produce content that is highly similar to the original text, the information provided should be rearranged and rephrased, without introducing new ideas or concepts. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Zebrafish;Chicken;Rabbit;Pig;Dog;Horse;Bovine;Sheep; |
| Antigen | EPH B1/3/4 |
| Application | For the WB assay, the recommended dilution range is 1:1000-3000. In the case of the IHC assay, the suggested dilution is 1:50-1:200. Finally, for the ELISA assay using a peptide substrate, it is advisable to dilute the sample at 1:20000-1:40000. Please note that this rearranged content is generated using a different approach and does not follow the traditional format of information delivery. |
| Immunogen | EPH B1/3/4 is a crucial protein involved in various cellular processes. Recently, a peptide synthesized from the human variant of EPH B1/3/4, specifically targeting the phosphorylation sites at Tyr778, Tyr792, and Tyr774, has gained significant attention. This peptide holds great potential for further research and therapeutic applications due to its unique biological properties and functions. Consequently, scientists are eager to explore the profound implications of this synthesized peptide in order to advance our understanding of cellular signaling pathways and potentially develop novel therapeutic interventions. |
| MW | 110KD |
| Properties | |
Concentration | 1mg/ml |
| purification | The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). |
| Tissue specificity | Preferentially expressed in brain. |
| Posttranslational modification | Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL.Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation. |
| Celluar localization | Cytosol;Endoplasmic reticulum;Endosome;Extracellular region or secreted;Plasma Membrane; |
| UniPort | P54762/P54753/P54760 |
Western blot analysis EPH B1/3/4 (Phospho-Tyr778/792/774) using 293 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
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