Rabbit Anti-LAMP3 Polyclonal Antibody #abs124273

abs124273-50ul

In Stock

201

abs124273-100ul

In Stock

301

Other names

The DC-lysosome-associated membrane glycoprotein, also known as CD208 or CD208 antigen, is a protein that plays a crucial role in the lysosomal function within dendritic cells (DCs). It is also referred to as DC LAMP, DCLAMP, LAMP, LAMP 3, or LAMP-3. Additionally, it is encoded by the LAMP3 gene and has the alternative names Protein TSC403 and TSC403.
LAMP3 is an essential component of the lysosomal membrane in DCs, aiding in the fusion of lysosomes with endocytic compartments. This fusion process is essential for the degradation of internalized molecules, antigen presentation, and immune responses. The protein TSC403 is highly specific to DCs and is used as a marker for identifying these cells.
Lysosomal-associated membrane protein 3 (LAMP-3) is predominantly located in the membranes of lysosomes and late endosomes. It serves as a recognition molecule in the interaction between lysosomes and other vesicles. Furthermore, LAMP-3 plays a critical role in maintaining the acidic pH and protease activity within lysosomes.
Lysosome-associated membrane glycoprotein 3 (LAMP3) is involved in various cellular processes, including autophagy, phagocytosis, and antigen presentation. It helps promote the maturation and activation of DCs, contributing to efficient immune responses.
In summary, the DC-lysosome-associated membrane glycoprotein, or CD208, is a key player in the lysosomal function within dendritic cells. It is encoded by the LAMP3 gene and has various alternative names like LAMP, LAMP-3, or LAMP3. This protein is primarily localized to lysosomal membranes and is involved in antigen presentation, immune responses, and maintaining the acidic pH of lysosomes.

Source

Rabbit

Specificity

LAMP3

Species Reactivity

Human;Mouse;Rat;Cow;Horse;Rabbit;

Application

The working dilutions for WB, ELISA, IHC-F, Flow-Cyt, and IF are as follows: WB requires a dilution of 1:500-2000, ELISA requires a dilution of 1:500-1000, IHC-F requires a dilution of 1:400-800, Flow-Cyt requires a dilution of 3ug/Test, and IF requires a dilution of 1:100-500 (Paraffin section requires antigen retrieval). Please note that these dilutions are based on the original text information and should be followed for accurate experimental results.

Immunogen

A synthetic peptide derived from human LAMP-3:301-416/416 has been conjugated with KLH. You can expect a highly similar performance with this conjugate, as it is based on the original sequence. The peptide has been carefully designed and synthesized to ensure that it is of high quality and purity. It can be used in various applications, including ELISA assays, Western blotting, and immunohistochemistry. This conjugate provides an excellent tool for investigating the role of LAMP-3 in various cellular processes. With this highly specific, high-quality peptide, you can confidently pursue your research goals.

Properties

Concentration

1mg/ml

Purification

affinity purified by Protein A

Clonality

Polyclonal Antibody

Isotype

IgG

Stability & Storage

To ensure the preservation of the product, it is recommended to store it at -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing.

Storage buffer

0.01M TBS(pH7.4)、1% BSA、0.03% Proclin30050%，，。

Research area

Cancer stem cells

Target

Background

LAMP3, a protein found in the lysosome, appears to affect the function of this organelle after peptide MHC class II molecules are transferred onto dendritic cells. Overexpression of this protein has been linked to an increased risk of metastasis and may serve as a prognostic factor for cervical cancer. LAMP3 is commonly expressed in lymphoid organs, dendritic cells, and the lungs, and its expression is typically upregulated in various types of carcinomas, such as those of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid, and parotid tissues.

UniPort

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