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Phospho-CRMP-1 (Tyr504) Rabbit Polyclonal Antibody#abs140087

Please note that the price provided above is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. Western blot analysis CRMP-1 (Phospho-Tyr504) using Paclitaxel treated HeLa whole cell lysates This product is for research use only, not for use...

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Description

Catalog-specification	Delivery time	USD price
abs140087-100ug	1-2 Weeks	301.0
abs140087-50ug	1-2 Weeks	201.0

Please note that the price provided above is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent.

Overview
catalog	abs140087
Other names	Protein 1 mediator response Collapsin; CRMP 1; CRMP-1; Crmp1; Like 1 dihydropyrimidinase; Related protein 1 dihydropyrimidinase; Related protein 1 dihydropyrimidinase; DPYL1_HUMAN; DPYSL1; DRP 1; DRP-1; DRP1; ULIP-3; Ulip3; 3 phosphoprotein-like Unc-33. The protein known as Collapsin response mediator protein 1, or CRMP 1 for short, is also referred to by several other names such as CRMP-1, Crmp1, Dihydropyrimidinase like 1, and Dihydropyrimidinase related protein 1. It is a member of the dihydropyrimidinase family and shares similarity with Dihydropyrimidinase-related protein 1. In scientific literature, it is commonly abbreviated as DPYL1_HUMAN or DPYSL1. Additionally, it is sometimes referred to as DRP 1 or DRP-1, as well as DRP1. ULIP-3 and Ulip3 are alternative names for this protein. Another name for it is Unc-33-like phosphoprotein 3. Overall, these names all refer to the same protein, which plays a role in mediating the cellular response to collapsin, a protein involved in growth cone collapse and neuronal guidance during development. Understanding the function and regulation of Collapsin response mediator protein 1 is important in unraveling the intricate processes of neuronal development and axon guidance.
Source	Rabbit
Specificity	The CRMP-1 (Phospho-Tyr504) Antibody is designed to identify phosphorylated CRMP-1 at Tyr504. It is specific to endogenous levels of CRMP-1, and does not detect non-phosphorylated forms of the protein. By targeting this specific phosphorylation site, the antibody enables researchers to gain insight into the function and regulation of CRMP-1 in various cellular processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	CRMP-1
Application	For western blotting, a dilution of 1:1000-3000 is recommended, while for immunohistochemistry a dilution of 1:50-1:200 is appropriate. For ELISA using a peptide, a dilution of 1:20000-1:40000 is suggested. It is important to note that these dilutions may vary depending on the specific application and should be optimized for each experiment. Proper dilutions ensure accurate and reliable results.
Immunogen	A synthetic peptide composed of human CRMP-1 (Phospho-Tyr504) has been developed. The peptide has been carefully designed to closely resemble the original protein sequence, and it shows great potential for use in biochemical and biomedical research. It is hoped that this new peptide will help to shed light on the biological functions of CRMP-1 and pave the way for the development of new therapies and treatments for various diseases. With its high level of similarity to the original protein, this synthesized peptide is poised to make a significant impact in the field of molecular biology.
MW	62KD
Properties
Concentration	1mg/ml
purification	The purification of the antibody involved sequential chromatography on phospho- and non-phospho-peptide affinity columns using purified rabbit serum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure preservation for a year, it is recommended to store the item at -20 °C and avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.
Tissue specificity	Brain.
Celluar localization	Cytoskeleton;Cytosol;
UniPort	Q14194