Recombinant Mouse Thymic Stromal Lymphopoietin Receptor/TSP R (C-Fc) #abs04475

abs04475-10ug

1-2 Weeks

230

abs04475-50ug

1-2 Weeks

673

abs04475-500ug

1-2 Weeks

2566

abs04475-1mg

1-2 Weeks

3491

Description

Our Mammalian expression system is utilized to create Recombinant Mouse Thymic stromal lymphopoietin protein receptor. The target gene comprises Ala20-Leu233, with a Fc tag located at the C-terminus. The resulting product is highly similar in composition to the original text information.

Other names

CRL2, also known as cytokine receptor-like 2 or IL-XR, is a cytokine receptor involved in various biological processes. It also has a precursor form called CRL2 cytokine receptor. CRLF2, another cytokine receptor-like factor 2, is sometimes referred to as CRLF2Y as well. In addition, there is CRLM-2, which is related to CRL2.
PCOR1 is another protein that interacts with cytokine receptors like CRL2. The P2RY8/CRLF2 fusion is a genetic mutation that arises when P2RY8 and CRLF2 genes combine. This fusion is present in some types of leukemia.
The thymic stromal lymphopoietin protein receptor (TSLP receptor) is a membrane protein that belongs to the cytokine receptor family. It is also known as the thymic stromal-derived lymphopoietin receptor (TSLPR).
In summary, CRL2, CRLF2, CRLM-2, PCOR1, P2RY8/CRLF2 fusion, and TSLP receptor are all related to cytokine signaling pathways and play important roles in various physiological processes.

Source

Human Cells

Format

The solution containing 20mM PB, 150mM NaCl, pH 7.4 was filtered using a 0.2 μm filter and then lyophilized to produce the final product. The resulting content thus obtained closely resembles the original solution and retains its composition and pH value.

Properties

aa_sequence

GLRVGGDWATSNVHPEASDTGQHLVAPGTPSSEPSCVLQSDGTWLGQNWVTACQALGLPGGSTAAARLEAGSAAVLVEPRMLVKKQPAGSAAWRVAVVEEPSLPPDPVNTMVASWRQQDEGTGITIRNMKAQMYSSNTYQQFGRVLPKGVQTSEPWASVYEEQEKGLAVKIFYANSTGAGDYLNWVPSDIMRQYDYGFHGNRPLTSSGVWHGPVTVDWEHGSDGLPVECEAIVKALKHSWCVLYELLKPTTQHKAVPVSMGIVHRPSTLQHVPAFQKVVDVPSKPVVTLIVPHEFRQATKFTTAAPSFYLVHVFTFNGTLLDLSSRTPDAITGGVQSWDYFLRASKLAVTVAVCQLYIHQPGVPHRYQVDDGTEQSKAPLNKDYTVVLKGKKYMCSSNVSLQTGLPSSNCSAQKTVYAVVTVPAYLNHAYYVFNWGTWRCYWDVQLLGGEAQVKTKCSADSSYLWASSIRGYLVKCDLVEPAEVLVVAHTKEEVVLAPCQRVLVENYVELLFYLFPSSDHVTHLPVPIQTMTKDVTFIVEKDGKIIGDVWEDEKYVIAGLDMINHYEEHAKRRVKMVIPGMAKELVRTLTNRVEYFPPKTCPDGLKEFVCEGSSLNLNLTEIADYQEKVYACEVTHQGLSSPVTCVVVDLELDVTVTGKLVEPKVSVFFTLKDDTVTLTCRACQKNSSGNLMPPVPVCLEARFLYGGSYTFGGGMVDLGSHISPLSVAILLSSFVPPVPS

Concentration

SDS-PAGE，95%。，。

Endotoxin_level

According to the results obtained from the LAL test, the concentration of less than 0.1 ng/μg (1 IEU/μg) was determined. This information confirms the extremely low levels of contamination present.

Activity

Measured by its ability to block human IL-15-induced proliferation of CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is typically 3.21 ng/mL

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target

Background

The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common γ receptor–like chain (TSLPR-γ) and a common interleukin 7 (IL-7) Rα chain that belongs to the type 1 cytokine receptor family. Transfection of TSLPR cDNA result in only low affinity binding, while cotransfection of the IL-7Rα chain cDNA shows high affinity binding. TSLP and TSLPR play a critical role in the initiation of allergic diseases in mice. The TSLP R cDNA encodes a transmembrane receptor containing 370 amino acids (aa) with two potential N-linked glycosylation sites and a cytoplasmic domain of 104 aa including a single tyrosine residue. TSLPR can mediate signaling of the signal transducer and activator of transcription 5 (Stat5) by TSLP. TSLP R is broadly expressed in the immune and hematopoietic cells, particularly in hematopoietic progenitors and myeloid cells.

Accession

Q8CII9