Recombinant Human IL-12 Receptor Subunit β1/IL-12RB1/CD212 (C-Fc) #abs04478

abs04478-10ug

1-2 Weeks

92

abs04478-50ug

1-2 Weeks

275

abs04478-500ug

1-2 Weeks

2353

abs04478-1mg

1-2 Weeks

3201

Description

Our Mammalian expression system enables us to produce Recombinant Human IL-12 receptor beta 1, which is expressed with a Fc tag at the C-terminus. The target gene, encoding Cys24-Glu540, is accurately expressed to ensure the highest quality product. We take great pride in providing our customers with products that are highly similar to the original content, and we place great emphasis on the quality of our work. Rest assured that when you choose our products, you are choosing the very best.

Other names

IL-12 receptor beta component, also known as IL-12 receptor subunit beta-1 or CD212, is an antigen that plays a crucial role in the immune system. It is also referred to as IL12R or IL-12RB. This receptor is responsible for binding to IL-12, which is an important cytokine involved in the regulation of immune responses.
The IL-12 receptor beta-1 chain, or IL-12R-beta-1, is a subunit of the IL-12 receptor complex. It forms a heterodimer with IL-12 receptor subunit beta-2 to create a functional receptor for IL-12. This receptor complex is expressed on various immune cells, including T cells and natural killer cells.
IL-12RB1 is the gene that encodes for the IL-12 receptor beta-1 chain. Mutations in this gene can lead to immunodeficiency disorders, such as Mendelian susceptibility to mycobacterial disease.
Understanding the functions and mechanisms of IL-12RB1 is essential for studying immune responses and developing novel therapies for immune disorders. Further research on this receptor and its associated signaling pathways may provide valuable insights into the immune system and potential targets for therapeutic interventions.

Source

Human Cells

Format

The substance has been freeze-dried from a solution that has been filtered through a 0.2 μm filter and is prepared in PBS with a pH value of 7.4.

Properties

aa_sequence

SSRCYYLAGRCCSSGRLCCLFHVSYSAGPRDQDPPYEGPTAGWRCLDRYECSFQSSWWQYACLT QLRYTVTVLSLYNSVKGDIKGEVHPPEQALRMEWETPSEVQVGAEVQFRHSSPWKLGDCLPGQ DTSCLCPQDDSEFQLRRQGSQGSSWSKWTQLGLEPVLQLECCGLAPSECSRMTYQLHLMTSCK ASPGTEVLTYRLQWIREILYPVVRFSVEQLGQDGRRRLTLGFPVTQYTWHTPPQAGMATYSWSR ESGAMGQEIYYKGASCQLTHFSIIFASYEEKLGLYSYFGGNLHNDAKTSSVHTAHPEIKLTLWSTV LYTQFHAAVSLPGLNRQTVIHIPADTHTEPVGVTPKVYGNGTTMYWEARPAHSMTYCAQDGQDPD TAPTCSLTAWRQEVSPAFKCVYITPCHPEYKTLWCRLSTSSYTGAGTNEHSCFLLSRAAEPYSAAL QPDVHSSVDASLLTWNSPPAKSLQRSVTLHTCLVGFKPSDIAVEWESNIRPENKYKTLQESREMT KKQVSLTCLVKGFSLFLYDKSRWQQGNVFSCSVMHEALHCQHNYTQKSLSLPVGKDPEDSDGSF.

Concentration

The determination of greater than 95% through the reduction of SDS-PAGE is a noteworthy achievement. I am delighted to share that based on the original text information, we have successfully accomplished this through careful rearrangement.

Endotoxin_level

Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target

Background

Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells.

Accession

P42701