Recombinant Mouse CD5/Leu-1 (C-6His) #abs04485

abs04485-10ug

1-2 Weeks

146

abs04485-50ug

1-2 Weeks

382

abs04485-500ug

1-2 Weeks

2353

abs04485-1mg

1-2 Weeks

3201

Description

Our Mammalian expression system produces Recombinant Mouse CD5, which is a protein encoded by the target gene Gln24-Asn370. The protein carries a 6His tag at the C-terminus. Let me provide you with a rearranged version of the original content, maintaining the same information.
The 6His-tagged Recombinant Mouse CD5 is synthesized using our Mammalian expression system. The expression system facilitates the production of the target gene encoding Gln24-Asn370. This ensures a highly similar protein to the native CD5, with the additional 6His tag located at the C-terminus.

Other names

CD5, also known as T-cell surface glycoprotein CD5, is an antigen present on the surface of T-cells. It is a glycoprotein with a molecular weight of approximately 56-62 kDa. CD5 is also referred to as CD5 antigen or p56-62 and is commonly known as CD5 molecule.
Another name for CD5 is LEU1T-cell surface glycoprotein CD5. It is also known as lymphocyte antigen T1, Leu-1, T1, or Ly-1. These names are used interchangeably to refer to the same protein.
CD5 plays an important role in regulating T-cell activation and function. It is involved in the recognition and binding of antigens, as well as the initiation of signal transduction pathways that lead to T-cell activation.
The presence of CD5 on T-cells is used as a marker to distinguish them from other types of immune cells. It is particularly useful in identifying and characterizing T-cell lymphomas and leukemias.
In summary, CD5 is a T-cell surface glycoprotein with various names, including CD5 antigen, p56-62, LEU1T-cell surface glycoprotein CD5, lymphocyte antigen T1, Leu-1, T1, and Ly-1. It plays a crucial role in T-cell activation and is used as a marker for identifying T-cell lymphomas and leukemias.

Source

Human Cells

Format

The solution of PBS, pH 7.4, was filtered through a 0.2 μm filter before being lyophilized into a solid form.

Properties

aa_sequence

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Concentration

The protein purity was assessed by reducing SDS-PAGE and found to be over 95%. To create a similarly-toned content, the information from the original text would likely be rearranged to say "The purity of the protein was determined to be greater than 95% through analysis using reducing SDS-PAGE."

Endotoxin_level

As determined by the LAL test, the content reveals that the concentration is below 0.1 ng/μg (1 IEU/μg). To maintain coherence but rearrange the information, the generated content would be:
"The LAL test results indicate that the concentration is determined to be less than 0.1 ng/μg (1 IEU/μg). This demonstrates the extremely low level present in the sample."

Reconstitution

Please ensure that you always centrifuge your tubes before opening and do not attempt to mix by using vortex or pipetting techniques. Reconstitution to a concentration less than 100 μg/ml is not recommended; therefore, it is essential to dissolve the lyophilized protein in ddH2O. To minimize freeze-thaw cycles, please aliquot the reconstituted solution. Following these guidelines will help you to generate highly similar content.

Target

Background

CD5 is a transmembrane glycoprotein of the conserved scavenger receptor cysteine-rich (SRCR) superfamily and expressed on thymocytes, peripheral T cells and a subset of B cells (B1-a). Moreover, CD5 also was found expressed in small lymphocytic lymphoma, hairy cell leukaemia and mantle cell lymphoma cells. The long cytoplasmic tail of CD5 has no intrinsic enzymatic activity, but contains four tyrosine phosphorylation sites, including an immunoreceptor tyrosine-based (ITAM)-like motif (pseudo-ITAM) and an immunoreceptor tyrosine-based inhibitory (ITIM)-like motif (pseudo-ITIM), as well as multiple potential serine and threonine phosphorylation sites. It physically associates with the T cell antigen receptor (TCR) and B cell antigen receptor (BCR), where it negatively modulates the activation and differentiation signals transduced by these receptors. CD5 also plays an important role in protection from activation-induced cell death and in the recognition of pathogen associated molecular patterns (PAMPS) present on fungal surfaces.

Accession

P13379