Recombinant Human T-cell Immunoglobulin Mucin Receptor 3 / TIM-3 Protein #abs02005

abs02005-10ug

1-2 Weeks

115

abs02005-100ug

1-2 Weeks

497

Description

We utilized mammalian cells to produce recombinant human TIM3 protein aa1-201, which is tagged with His-DYK at the C-terminal end. The predicted molecular weight of the recombinant TIM3 is 22.1 kDa. Upon purification, the SDS-PAGE analysis revealed that the purified TIM3 protein appears between the 43-26 kDa range under reduced conditions. This indicates the successful production and isolation of the desired protein.

Our company has developed exclusive chromatographic methods to extract and purify the TIM3 protein. Through these proprietary techniques, we are able to obtain a highly pure form of the protein for various research and commercial applications.

Entrez Gene summary for TIM3:

The gene in question produces a protein that belongs to the TIM family of proteins and the immunoglobulin superfamily. CD4-positive T helper lymphocytes are essential in identifying two types, namely Th1 and Th2, based on their cytokine secretion patterns. While the former provides immunity against intracellular pathogens and triggers delayed hypersensitivity reactions, the latter focus on controlling extracellular helminthic infections and encourage atopic and allergic diseases. This molecule is a Th1-specific cell surface protein that plays a crucial role in regulating macrophage activation. It also curbs the Th1-mediated auto- and alloimmune responses, thus promoting immunological tolerance.

UniProtKB/Swiss-Prot: Q8TDQ0 (HAVR2_HUMAN)

This particular cell surface receptor is believed to play a significant role in regulating both the innate and adaptive immune responses. It is widely acknowledged to exert an inhibitory influence on these immune processes.

Other names

TIMD-3, also known as T-cell immunoglobulin and mucin domain-containing protein 3, is a molecule of great interest in the field of immunology. This protein plays a crucial role in modulating immune responses and has been found to be expressed on various immune cells, including T cells. By rearranging the content, we can provide a new perspective on TIMD-3 and its significance in immunological research.
The scientific community has shown a keen interest in understanding the functions of TIMD-3, a remarkable molecule known as T-cell immunoglobulin and mucin domain-containing protein 3. This protein, expressed on different immune cells, particularly T cells, holds immense potential for regulating immune responses. Its unique structure and properties have captivated researchers, leading to extensive investigations into its role in immunology.
Researchers have made significant strides in unraveling the various aspects of TIMD-3, shedding light on its fascinating functions in the immune system. The presence of this protein on T cells suggests its involvement in the regulation of T cell responses, making it a key player in the intricate network of immune signaling. Understanding the specific mechanisms through which TIMD-3 influences immune responses is a crucial step towards developing therapeutic strategies to modulate immune-mediated diseases.
Moreover, the exploration of TIMD-3 extends beyond T cells, as this protein has been identified on other immune cell types as well. This diverse expression pattern hints at broader roles in immune modulation, emphasizing the need for comprehensive studies to fully comprehend its significance. By investigating TIMD-3's interactions with other immune molecules and deciphering its downstream signaling events, scientists aim to uncover novel therapeutic targets and potential biomarkers for immune-related disorders.
In conclusion, TIMD-3, or T-cell immunoglobulin and mucin domain-containing protein 3, is a fascinating molecule with immense potential in immunological research. Its unique expression on T cells and other immune cells highlights its regulatory role in immune responses. By delving deeper into the mechanisms and functions of TIMD-3, scientists aim to unlock valuable insights that could pave the way for innovative immunotherapies and diagnostics in the future.

T-cell immunoglobulin mucin receptor 3 / TIM-3

T-cell membrane protein 3

Source

Mammalian cells

Format

The solution for the protein contains Tris at a concentration of 20 mM, NaCl at 150 mM, glycerol at 10%, and has a pH of 7.5.

Properties

Stability & Storage

The recommended storage condition for the clear solution is at -70°C. It is advisable to aliquot the solution and keep it at -70°C during the first use to prevent the need for multiple freeze-thaw cycles.

Target

Accession

NP_116171.3