Recombinant 2019-nCoV S2 Protein (C-Fc) #abs04709

abs04709-50ug

1-2 Weeks

310

Description

Our Mammalian expression system has produced Recombinant 2019-nCoV S2 Protein with a Fc tag at the C-terminus. We strive to preserve the original information while offering a new perspective on the matter.

Other names

Spike protein S2, also known as S glycoprotein Subunit2 or Spike glycoprotein Subunit2, plays a crucial role in the 2019-nCoV virus (Mammalian, C-Fc). This protein, termed COVID-19, is of paramount importance in understanding the mechanisms of the novel coronavirus. By rearranging the provided information, we can generate a highly similar content with a different presentation:
Exploring the depths of the 2019-nCoV virus, we encounter the enigmatic S2 protein. This mammalian variant, known as Spike glycoprotein Subunit2, serves as a pivotal component of the virus. Its significance lies in its role as a crucial subunit of the S glycoprotein. The Spike protein S2, popularly referred to as COVID-19, encapsulates the essence of the virus, standing as a gateway to comprehend its inner workings.

Source

Human Cells

MW

The molecular mass of the compound is 84.1 kiloDaltons, while the molecular mass under reducing conditions ranges from 100 to 130 kiloDaltons. Hence, there is a significant difference in the size of the molecule depending on the presence of reducing agents. It is important to note that the above information provides valuable insights for researchers and scientists who aim to study the properties and behavior of the compound in different conditions.

Format

The provided solution is a filtered solution of PBS with a concentration of 0.2 μM and a pH of 7.4. Can you please provide additional details or specifications?

Properties

Purification

Affinity purification chromatography.

Concentration

We have determined that the protein purity is greater than 95% through SDS-PAGE analysis. In other words, the level of impurities in the sample is very low, indicating a high degree of protein purity. This is a promising result and demonstrates the effectiveness of our purification process.

Stability & Storage

It is recommended to store the reconstituted protein solution in a freezer at a temperature of no higher than -20°C to maintain its quality and stability. It is important to adhere to this storage requirement to ensure that the protein remains viable for further use.

Target

Background

Protein S (PROS1) is a glycoprotein present in various cell types, and its involvement in multiple biological processes has been reported. These processes include coagulation, apoptosis, cancer development and progression, and the innate immune response. Several known receptors, such as ACE2, DPP4, CEACAM, etc., can bind to the S1 region of protein S. The spike (S) glycoprotein of coronaviruses, particularly the severe acute respiratory syndrome (SARS), is crucial for the virus to attach to the host cell during the initial stages of infection. The SARS-CoV spike protein alone can facilitate the fusion of membranes required for virus entry and cell fusion. It serves as a significant immunogen and a target for entry inhibitors. Recent studies have shown that 2019-nCoV can infect human respiratory epithelial cells by interacting with the human ACE2 receptor. The spike protein is a large transmembrane protein comprising two subunits, S1 and S2. The S1 subunit primarily consists of a receptor binding domain (RBD) responsible for recognizing the cell surface receptor. On the other hand, the S2 subunit possesses essential elements for membrane fusion. The S protein plays a vital role in inducing neutralizing antibodies and T-cell responses, leading to protective immunity.